Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Katz WS et al. (1996) Mol Cell Biol "A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Katz WS et al. (1996) Mol Cell Biol "A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog." (0)

  • Overview

    PMID:
    8552080
    DOI:
    10.1128/MCB.16.2.529
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00002375

    Katz WS, Lesa GM, Yannoukakos D, Clandinin TR, Schlessinger J, & Sternberg PW (1996). A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol, 16, 529-37. doi:10.1128/MCB.16.2.529

    The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation alters a conserved cysteine residue in the extracellular domain and is the first such point mutation in the EGFR subfamily of tyrosine kinases. Mutation of a different cysteine in the same subdomain causes a strong loss-of-function phenotype, suggesting that cysteines in this region are important for function and nonequivalent. Vulval precursor cells can generate either of two subsets of vulval cells (distinct fates) in response to sa62 activity. The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates.

    Affiliation:
    - Howard Hughes Medical Institute, California Institute of Technology, Pasadena, 91125, USA.

    Keywords:
    Tip: Seeing your name marked red? Please help us identify you.