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Resources » Paper

Heschl MFP et al. (1990) Comp Biochem Physiol B "The HSP70 multigene family of Caenorhabditis elegans."

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  • Overview

    PMID:
    2225768
    DOI:
    10.1016/0305-0491(90)90206-9
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00001320

    Heschl MFP, & Baillie DL (1990). The HSP70 multigene family of Caenorhabditis elegans. Comp Biochem Physiol B, 96, 633-7. doi:10.1016/0305-0491(90)90206-9

    1. The heat shock response of the nematode Caenorhabditis elegans has been characterized. 2. There are at least nine genes in the hsp70 multigene family of C. elegans. 3. Five of the hsp70 genes have been characterized and assigned to one of at least three hsp70 gene subfamilies. One of the subfamilies consists of an hsp70 protein that has the potential to be translocated into the endoplasmic reticulum and another subfamily consists of a protein that has the potential to be translocated into the mitochondria. 4. The C. elegans hsp70 multigene family has several unique characteristics including introns in the heat inducible hsp70 genes, at least one trans-spliced hsp70 mRNA and two grp78 related genes, one of which is highly heat inducible. 5. The identification and characterization of C. elegans hsp70 multigene family is the basis for a genetic characterization of the regulation and function of a gene family during the development of a multicellular eukaryote.

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