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Resources » Paper

Mori I et al. (1990) Mol Gen Genet "Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans."

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  • Comments on Mori I et al. (1990) Mol Gen Genet "Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    2157953
    DOI:
    10.1007/BF00260490
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00001239

    Mori I, Moerman DG, & Waterston RH (1990). Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans. Mol Gen Genet, 220, 251-5. doi:10.1007/BF00260490

    We report here an unusual activation of the Tc1 transposable element system in Caenorhabditis elegans. Germline Tc1 activity, as measured by reversion of unc-22::Tc1 alleles, is elevated 50- to 100-fold by certain crosses. For example, unc-22::Tc1 reversion is 1 x 10(-3) in a mut-6 IV strain and less than 1 x 10(-6) in a non-mutator strain, but in the unc-22::Tc1 progeny of a cross between mut-6 hermaphrodites and non-mutator males, reversion is 10(-1). The reciprocal cross does not induce this enhancement of reversion. Results similar to those for mut-6 were obtained using a mut-5 II strain. The mutator hermaphrodite by nonmutator male cross per se is not required for the enhancement of reversion, as mut-5 hermaphrodites x mut-6/+ males also induce unc-22 revertants at an elevated frequency. This reversion enhancement appears to depend on a maternal component inherited from a mutator strain, suggesting that the regulation of Tc1 activity may be complex.

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