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Resources » Paper

Kramer JM et al. (1988) Cell "The sqt-1 gene of C. elegans encodes a collagen critical for organismal morphogenesis."

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  • Comments on Kramer JM et al. (1988) Cell "The sqt-1 gene of C. elegans encodes a collagen critical for organismal morphogenesis." (0)

  • Overview

    PMID:
    3180220
    DOI:
    10.1016/0092-8674(88)90214-0
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00001100

    Kramer JM, Johnson JJ, Edgar RS, Basch C, & Roberts SB (1988). The sqt-1 gene of C. elegans encodes a collagen critical for organismal morphogenesis. Cell, 55, 555-65. doi:10.1016/0092-8674(88)90214-0

    Different mutations in the sqt-1 gene of C. elegans can lengthen, shorten, or helically twist the entire animal. We have cloned the sqt- 1 gene and have shown that it encodes a collagen. sqt-1 was localized to a 35 kb region of DNA by physical mapping of chromosomal deficiencies. A transposon (Tc1)-induced mutation of sqt-1 was generated and utilized to identify the sqt-1 gene within this 35 kb region. Sequence analysis of the sqt-1 gene shows that it encodes a 32 kd collagen polypeptide that is similar in size and structure to other members of the C. elegans collagen family. The Tc1 insertion mutant has no detectable sqt-1 transcripts, yet it is morphologically normal, indicating that the null phenotype of sqt-1 is wild type. These results demonstrate that collagen mutations can have dramatic effects on organismal morphology.

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