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Comments on Wood WB et al. (1985) Cold Spring Harb Symp Quant Biol "Aspects of dosage compensation and sex determination in Caenorhabditis elegans." (0)
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Wood WB, Meneely PM, Schedin P, & Donahue LM (1985). Aspects of dosage compensation and sex determination in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol, 50, 575-83. doi:10.1101/SQB.1985.050.01.070
The nematode Caenorhabditis elegans has two sexes, hermaphrodites and males. Hermaphrodites normally have two X chromosomes (XX or 2X) and males only one (XO or 1X). There is no Y chromosome, and sex is determined by the X/A ratio, i.e., the ratio of X chromosomes to sets of autosomes. The X/A ratio acts to determine sex through a set of at least seven interacting autosomal genes, which have been defined, characterized, and shown to act as a regulatory pathway, primarily by Hodgkin and co-workers. The first gene in the pathway, her-1, acts through five intervening genes to regulate the major switch gene tra-1, whose activity determines somatic sexual development. At an X/A ratio of 1.0, her-1 activity is low and tra-1 acivity is high, leading to hermaphrodite development. At an X/A ratio of 0.5, her-1 activity is high and tra-1 activity is low, leading to male development. Loss-of-function mutations in the her-1 gene transform 1X animals into fertile hermaphrodites and have no effect on 2X hermaphrodites. Loss-of-function mutations in the tra-1 gene transform 2X animals into fertile males and have no effect on 1X males....
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