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Resources » Paper

Emmons SW et al. (1980) J Mol Biol "Arrangement of repeated sequences in the DNA of the nematode Caenorhabditis elegans."

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  • Comments on Emmons SW et al. (1980) J Mol Biol "Arrangement of repeated sequences in the DNA of the nematode Caenorhabditis elegans." (0)

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    PMID:
    7253025
    DOI:
    10.1016/0022-2836(80)90333-2
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00000492

    Emmons SW, Rosenzweig WD, & Hirsh DI (1980). Arrangement of repeated sequences in the DNA of the nematode Caenorhabditis elegans. J Mol Biol, 144, 481-500. doi:10.1016/0022-2836(80)90333-2

    The arrangement of repeated sequences in the DNA of the nematode Caenorhabditis elegans has been studied by electron microscopy and reassociation kinetics. Inverted repeats observed in the electron microscope are mostly less than 1000 base-pairs in length and are distributed randomly with an average separation of 33,000 bases. Comparison of the number and distribution of these inverted repeats with the amount of DNA in the foldback fraction isolated by hydroxyapatite chromatography suggests that much of the material in the foldback fraction contains a sequence distinct from the class of inverted repeats observed in the electron microscope. Cot analysis of DNA fragments several thousand nucleotides in length shows that moderately repetitive sequences are interspersed with unique sequences. Most of these interspersed, repeated sequences are a few hundred nucleotides in length, as determined from electron micrographs. DNA sequence arrangement in C. elegans is therefore similar to the arrangement found in most other eukaryotes.

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