Vrbanac A et al. (2017) Cell Host Microbe "An Elegan(t) Screen for Drug-Microbe Interactions."

Morton JT, Debelius JW, Knight R, Jiang L, Dorrestein P, Vrbanac A

[Cell Host Microbe, 2017]

Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C.elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, Garcia-Gonzalez etal. (2017) and Scott etal. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.