ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

ENA2

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

HAL9

Saccharomyces cerevisiae

Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication

ISC1

Saccharomyces cerevisiae

Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2

PKLR

Homo sapiens

Isoform R-type of Pyruvate kinase isozymes R/L

BDH1

Saccharomyces cerevisiae

NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source

TNR

Homo sapiens

Isoform 1 of Tenascin-R

RRAS2

Homo sapiens

Ras-related protein R-Ras2

MSRB1

Homo sapiens

Methionine-R-sulfoxide reductase B1

RRAS

Homo sapiens

Ras-related protein R-Ras