Picture from Kerk SY et al. (2017) Neuron "Diversification of C.elegans Motor Neuron Identity via Selective Effector Gene ...."

(D) bnc-1 is derepressed in DA/DB MNs in mab-9 mutants. WT image repeated from Figure 2E. A bnc-1 promoter 1.8 kb upstream of the start codon recapitulatesthe VA/VB-specific expression of endogenous bnc-1. Mutation (mut-) of MAB-9 binding sites causes bnc-1 to be derepressed in DA/DB MNs. All rfp representsmchopti+h2b. See Figure S1H for quantification.(E) bnc-1 fluorescent reporters of the endogenous gene locus (CRISPR; see Figure 2E), a fosmid (see Figure S1G), the rescue construct used in Figures 2A and 2B(see Figure S1G), and the abovementioned 1.8-kb promoter (see Figure 3D) express specifically in VA/VB MNs. Deletion of MAB-9 binding sites (white-filledvertical rectangle) causes bnc-1 to be derepressed in DA/DB MNs. See Figure S1H for quantification.

Picture from Gordon PM et al. (2015) Dev Cell "A competition mechanism for a homeotic neuron identity transformation in C. ...."

Figure 1. Control of BDU Neuron Identity(A) Schematic drawing of ALM and BDU morphology.(B) Timing of TF expression. See Figure S1B for expression data and cross-regulation of TFs.(C) Lineage and terminal markers of ALM and BDU. +, expressed; , not expressed.(D) Responses to harsh touch (see Experimental Procedures). n is given at the bottom of each bar. Error bars expressed as SEM. **p < 0.001 ***p < 0.0001 (t test with Bonferroni correction). See Figure S1A for additional mutant analysis, rescue experiments, and further controls.(E) The effect of unc-86, pag-3, and ceh-14 on BDU identity. n R 50 for each reporter. Significance is indicated in relation to wild-type tested with Fischer's exact test. ***p % 0.0001, *p % 0.05. See Supplemental Experimental Procedures for information on reporter transgenes.

Picture from Gordon PM et al. (2015) Dev Cell "A competition mechanism for a homeotic neuron identity transformation in C. ...."

(E) The effect of unc-86, pag-3, and ceh-14 on BDU identity. n R 50 for each reporter. Significance is indicated in relation to wild-type tested with Fischer's exact test. ***p % 0.0001, *p % 0.05. See Supplemental Experimental Procedures for information on reporter transgenes.

Picture from Denning DP et al. (2013) PLoS Genet "Both the caspase CSP-1 and a caspase-independent pathway promote programmed ...."

(E) A model depicting the genetic pathways regulating the caspase genes csp- 1 and ced-3 (see text).

Picture from Cha DS et al. (2012) Gene Expr Patterns "Differential subcellular localization of DNA topoisomerase-1 isoforms and ...."

(A and B) TOP-1b is expressed in the nuclei of the most germ cells and strongly DTC (see inset).

Picture from Linhart C et al. (2012) Genome Res "A novel candidate cis-regulatory motif pair in the promoters of germline and ...."

Expression pattern of additional WT pas-5p::GFP worms from each of the transgenic lines tested (see Figure 3 and Supp. Fig. 4).

Picture from Sin O et al. (2017) Mol Cell "Identification of an RNA Polymerase III Regulator Linked to Disease-Associated ...."

(A) Subcellular localization of MOAG-2/LIR-3 in wild-type N2 worms. Scale bar, 50 mm. Arrowheads point at nuclei; asterisk is non-specific staining. See alsoFigure S2A.

Picture from Miki TS et al. (2014) Mol Cell "PAXT-1 promotes XRN2 activity by stabilizing it through a conserved ...."

(E) Worms expressing GFP/PAXT-1 on chromosome II from the paxt-1 operon promoter were observed by epifluorescence microscopy. Scale bar, 50 um.Arrowheads point to nucleoli. See also Figure S1.

Picture from Saltzman AL et al. (2018) Genetics "Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline ...."

(A) Relative expression levels of CEC-1 and CEC-6 across developmental stages. The 3xHA(hemagglutinin) epitope was inserted in frame at the endogenous locus using CRISPR/Cas9 genomeediting (see also Supplemental Material, Figure S3C). L1-L4, larval stages 1-4.(B) Localization of CEC-1 and CEC-6 by anti-HA tag immunofluorescence in embryos and L1animals. The arrowheads (B, lower right) indicate the primordial germ cells (see also SupplementalMaterial, Figure S3D).

Picture from Harrington RJ et al. (2002) Development "The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph ...."

Northern blot of total C. elegans mRNA extracted from mixed-stage populations, probed with the PTP-3B cDNA (see Materials and Methods). Messages of approx. 8 kb and approx. 5 kb are detected.