Picture from Phillips CM et al. (2006) Dev Cell "A family of zinc-finger proteins is required for chromosome-specific pairing ...."

Figure 5. ZIM Proteins Localize to Autosomal Pairing Centers(A-D) ZIM-1 colocalizes the left ends of chromosomes II and III. Two arrows point to the two ZIM-1 foci in a single nucleus and to the chromosomes II and III FISH probes, which colocalize with them.(E-H) ZIM-2 colocalizes with a FISH probe to the right end of chromosome V. A particularly clear example of this colocalization is indicated bythe arrow.(I-P) ZIM-3 colocalizes with FISH probes to the right end of chromosome I (I-L) and the left end of chromosome IV (M-P). Arrows point to clear examples. (A, E, I, and M) Late transition zone or early pachytene nuclei stained with DAPI. (B, F, J, and N) Immunolocalization of ZIM-1, ZIM-2,ZIM-3, and ZIM-3, respectively. (C, G, K, and O) FISH signals corresponding to IIL, IIIL, VR, IR, and IVL. (D, H, L, and P) Merged images.(Q) Correspondence of ZIM-1, -2, -3, and HIM-8 to the PC regions of the six C. elegans chromosomes. The region to which the PCs have been mapped genetically are demarcated in blue. Scale bars represent 5 um.