Picture from Xiao H et al. (2009) Mol Biol Cell "Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in ...."

Expression of VPS-18. (A) VPS-18::GFP expression in embryo (a and b), larva (c and d), adult coelomocyte (e and f), and germline (g and h) as well as the dissected-out germline (i and j). Arrows in (h and j) indicate germline sheath cells. The scale bars represent 20 um (a-d, i, and j), 5 um (e and f), and 10 um (g and h).

Picture from Lee HC et al. (2008) Mol Biol Cell "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for ...."

Expression of MBOA-7::GFP in an early embryo (D and E) and a second-stage larva (F and G). Nomarski micrographs (D and F) and corresponding MBOA-7::GFP expression (E and G). MBOA-7::GFP was ubiquitously expressed throughout development. Asterisks indicate the anterior of the larva (F and G). Bar, 10 um (D and E) and 200 um (F and G).

Picture from Schvarzstein M et al. (2006) Dev Cell "The C. elegans sex-determining GLI protein TRA-1A is regulated by sex-specific ...."

(B-I) (B, D, F, and G) Differential interference contrast micrographs and (C, E, H, and I) TRA-1 immunofluorescence of adult nematodes: (B and C) tra-1; eDp6[tra-1(+)] XX hermaphrodite and (D and E) a tra-1(null) mutant XX pseudomale sibling; (F and H) tra-1(+) XX hermaphrodite and (G and I) a tra-1(+) XO male sibling. Exposure times in (C) and (E) are identical, as are exposure times in (H) and (I).(J and K) DAPI staining of the animals in (F) and (G).

Picture from Srayko MA et al. (2000) Genes Dev "MEI-1/MEI-2 katanin-like microtubule severing activity is required for ...."

Figure 7. MEI-1 and MEI-2 immunolocation. Spindles from wild-type (WT) and mei-1(ct46gf) mutant embryos were fixed and immunostained with anti-MEI-1 (A and C) and anti-MEI-2 (B and D). In wild type (A and B), MEI-1 and MEI-2 were found at meiotic spindle poles (out of focal plane, white arrowheads) and chromatin (clear arrowheads). In mei-1(ct46gf) (C and D), MEI-1 and MEI-2 were found at centrosomes (white arrowheads) and chromatin (clear arrowheads). Bar; 2 μm. Embryos in C and D have approximately 10 cells; a close-up of one metaphase spindle from each embryo is shown.

Picture from Zhang D et al. (2012) J Cell Biol "RAB-6.2 and the retromer regulate glutamate receptor recycling through a ...."

Figure 10. RAB-6.2 and LIN-10 colocalize with RME-8 in neurons. (A-D) Fluorescence from neuron cell bodies (A and C) and ventral cord dendrites (B and D) is shown. (A-B'') Cerulean::RAB-6.2 (A and B) colocalizes with Venus::RME-8 (A' and B'; A'' and B'' show merged). (C-D'') LIN-10::CFP (C and D) colocalizes with Venus::RME-8 (C' and D'; C'' and D'' show merged). Arrowheads indicate colabeled puncta. Bars, 5 um.

Picture from Haithcock E et al. (2005) Proc Natl Acad Sci U S A "Age-related changes of nuclear architecture in Caenorhabditis ...."

Figure 1. The nuclear lamina undergoes progressive changes in aging nematodes. The nuclear lamina morphology as revealed in live C. elegans animals by LMN-1::GFP in days 4 (A),8(B), 12 (C), 15 (D) and 18 (E and F) animals under a confocal microscope. (G and H) Higher magnification confocal images of typical nuclei in days 12 (G) and 18 (H). Notice the folding of the nuclear lamina in G and the less distinct nuclear periphery and increased intranuclear localization of LMN-1::GFP in H. DAPI (I and K) and anti-LMN-1 antibody (J and L) staining of days 4 (I and J) and 14 (K and L) animals. Animals used in this experiment and the experiments in Figs. 2 and 5 were grown at 16C from eggs until day 4. They were then shifted to 25C and allowed to grow at 25C until death. (Scale bars, 5 mm in G and H and 10 um in A-F and I-L.)

Picture from Song S et al. (2010) PLoS Genet "A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis ...."

Figure S1 The expression patterns of Wnt ligands in C. elegans. Top panels: fluorescence and bright field images of mCherry expressing embryos; middle and bottom panels: fluorescence and bright field images of adults (head to the left). (A and B) Pcwn- 1::mCherry and Pmom-2::mCherry are robustly expressed in the tail and weakly expressed in the vulva and body wall muscles. (B and C) Pegl-20::mCherry and Plin-44::mCherry are mainly expressed in the tail during the embryonic and adult stages.

Picture from Schvarzstein M et al. (2006) Dev Cell "The C. elegans sex-determining GLI protein TRA-1A is regulated by sex-specific ...."

Figure 1. Genetic Model of Somatic Sex Determination in C. elegans, and TRA-1 Localization in Males and Hermaphrodites. (A) Simplified representation of the genetic pathway that regulates somatic sex determination. Barred lines indicate negative interactions, and arrows indicate positive interactions. The X/A ratio regulates X chromosome dosage compensation and sex determination via xol-1 and the sdc genes. The pathway branches at the sdc genes, and only downstream genes involved in sex determination are shown. (See Meyer, 1997 for a review.)(B-I) (B, D, F, and G) Differential interference contrast micrographs and (C, E, H, and I) TRA-1 immunofluorescence of adult nematodes: (B and C) tra-1; eDp6[tra-1(+)] XX hermaphrodite and (D and E) a tra-1(null) mutant XX pseudomale sibling; (F and H) tra-1(+) XX hermaphrodite and (G and I) a tra-1(+) XO male sibling. Exposure times in (C) and (E) are identical, as are exposure times in (H) and (I).(J and K) DAPI staining of the animals in (F) and (G).

Picture from Troemel ER et al. (1995) Cell "Divergent seven transmembrane receptors are candidate chemosensory receptors ...."

(A and B) Expression of srb-6 in the ASH and ADL (A) and PHA and PHB (B) sensory neurons. ADF expression was weaker and is not obvious in this plane of focus. ASH and ADF morphologies are similar to that of ASK (Figure3); PHA and PHB are bipolar sensory neurons in the tail with posterior dendrites and anterior axons. Gut autofluorescence is visible at the anterior edge of this photograph. Anterior is at left and dorsal up.

Picture from Karabinos A et al. (2003) J Mol Biol "In vivo and in vitro evidence that the four essential intermediate filament (IF) ...."

Figure 4. Colocalization of B1 and MH4 antigens in C. elegans embryo and larva. The left half of the Figure gives rabbit anti-B1 specific immunofluorescence of embryos (A, C and E) and the larva (G) that were double-stained with the murine monoclonal antibody MH4 that detects proteins A1 to A3 (right half of the Figure). The arrowheads highlight coexpression/co-organization of the B1 and the MH4 antigens in the dorsal and ventral hypodermis (except for the seam) of the comma (A and B), 1.5-fold (C and D) and 3-fold (E and F) stage embryos and the larva (G and H).