Picture from Kim S et al. (2012) Genetics "SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation ...."

Figure 11 Model for the control of oocyte meiotic maturation in C. elegans. MSP signaling for oocyte meiotic maturation requires Gas- ACY-4-PKA activity in the gonadal sheath cells. PDE-6 and TWK-1 may function in the gonadal sheath cells as negative regulators of meiotic maturation. The gonadal sheath cells inhibit meiotic maturation in part via gap-junctional communication involving the innexins INX-8 and INX-9 in the gonadal sheath cells (T. Starich and D. Greenstein, unpublished data) and INX-14 and INX-22 in oocytes (Govindan et al. 2009). SACY-1 is a strong negative regulator of meiotic maturation that functions in the germ line upstream of, or in parallel to, the positive regulators OMA-1 and OMA-2. CoREST-like complex has a function in the germ line that is needed for the dependence of meiotic maturation on the Gas-ACY-4- PKA sheath cell pathway. For illustrative purposes, TWK-1 and sheath cell MSP binding activity are displayed in a localized fashion, though this is unlikely to be the case (Govidan et al. 2009; this work).