Picture from Francis MM et al. (2005) Neuron "The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic ...."

Figure 2. ACR-16 Is Expressed in Muscle and Is Required for Nicotine-Gated Currents. (A) Image of body wall muscles and the ventral nerve cord of a transgenic worm that expressed Pacr-16::GFP.(B) Image of muscle arms of a transgenic worm that expressed Pmyo-3::ACR-16::GFP.(C-G) Current records from voltage-clamped body wall muscle cells. (C-E) Current responses of wild-type worms (C), acr-16(ok789) mutants (D), and unc-29(x29) mutants (E) to pressure application of ACh, levamisole, or nicotine. Rescue refers to transgenic acr-16 mutants that expressed Pmyo-3::ACR-16. (F) Current response of unc-29(x29);acr-16(ok789) double mutant to pressure application of ACh. All drugs were used at a concentration of 100 μM. (G) Nerve-evoked current responses of wild-type, unc-29(x29), acr-16(ok789) or unc-29(x29);acr-16(ok789) worms.

Picture from Francis MM et al. (2005) Neuron "The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic ...."

(B) Image of muscle arms of a transgenic worm that expressed Pmyo-3::ACR-16::GFP.

Picture from Francis MM et al. (2005) Neuron "The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic ...."

Figure 3. CAM-1 Is Expressed in Both Neurons and Muscles. (A) Schematic diagram of a worm. (B) Confocal image of head region (boxed area in [A]) from a transgenic worm that expressed CAM-1::GFP. Indicated are the nerve ring (blue arrowhead), neuronal cell bodies (white arrowhead), and ventral nerve cord (arrow). (C) Confocal images of a transgenic L4 worm expressing CAM-1::YFP (red, upper) and unc-4::CFP (green, middle); merged image, lower. (D) Confocal images of the ventral nerve cord of a transgenic adult worm expressing CAM-1::YFP (red, top) and acr-2::SNB-1::CFP (middle, green); merged image, bottom. Arrowheads denote areas of punctate fluorescence. CAM-1 and SNB-1 were colocalized at most puncta (white arrowheads). However, SNB-1 puncta without accompanying CAM-1 puncta (blue arrowheads) and CAM-1 puncta without accompanying SNB-1 puncta (purple arrowhead) were infrequently observed. (E) Schematic diagram of a worm showing the region (box) represented in the confocal image of a transgenic worm expressing CAM-1::GFP (F). The worm has been rolled 90 degrees from the position depicted in (A) to visualize the ventral nerve cord and NMJ regions more clearly. Intense CAM-1::GFP fluorescence (arrows) is observed at the distal extent of muscle arms at points of contact with the ventral nerve cord (mu, muscle; v, vulva). The red line in (A) and (E) represents the ventral nerve cord.

Picture from Francis MM et al. (2005) Neuron "The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic ...."

(A) Image of body wall muscles and the ventral nerve cord of a transgenic worm that expressed Pacr-16::GFP.

Picture from Peters JD et al. (2023) MicroPubl Biol "Nicotinamide riboside functions during development while ...."

Figure 1. The effects of NR, BHB, or both in combination on C elegans lifespan when the compounds were present only during adulthood, during larval development and adulthood, or when NR was present only during larval development:A. 0.5 mM NR, 20 mM BHB, both, or neither were added starting at the L4 larval stage. B. 0.5 mM NR, 20 mM BHB, both, or neither were added starting at the L1 larval stage. C. 0.5 mM NR was present only during the L1 to L4 larval stages, 20 mM BHB was present only from the L4 larval stage throughout adulthood, both treatments were combined, or no addition was made.

Picture from Zheng C et al. (2013) PLoS Genet "Histone methylation restrains the expression of subtype-specific genes during ...."

Figure S2 Expression of uIs45 in the ventral nerve cord at various developmental times. Scale bar= 20 mm for the first four sets of images and 50 mm for the last three sets.

Picture from Tsushima H et al. (2013) PLoS One "A snapshot of the physical and functional wiring of the Eps15 homology domain ...."

(C) Images (epifluorescence) of hermaphrodites carrying the reps-1p::REPS-1::GFP transgene. Anterior is to the left, ventral down. NR: nerve ring, INT: intestine, ESC: excretory system, V: vulva, NC: nerve cord, M: muscle cell. The asterisks indicate nerve commissures. Bars: 100 mm in a, 20 mm in b, 10 mm in c and d.

Picture from Wiesel N et al. (2008) Proc Natl Acad Sci U S A "Laminopathic mutations interfere with the assembly, localization, and ...."

Immunostaining of Ce-emerin in wildtype C. elegans embryos (N2). Scale bar, 10 mm.

Picture from Suzuki Y et al. (2006) Genes Dev "Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN ...."

daf-18 mRNA is present in the germ line. Animals were examined using in situ hybridization. Bar, 0.1 mm.

Picture from Ghose P et al. (2013) PLoS Genet "Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia ...."

EAT-3::GFP was observed along ventral cord neurites of wild-type nematodes under conditions of normoxia. Bar, 5 mm.