Picture from Bender LB et al. (2006) Development "MES-4: an autosome-associated histone methyltransferase that participates in ...."

In a wild-type germ line, the MES-4 pattern is dynamic (Fong et al., 2002). MES-4 levels are highest in the distal mitotic region, drop to nearly undetectable levels at the transition zone, rise modestly during late pachytene, and become markedly enhanced after fertilization (see early embryos in the upper half of panel). MES-4 is not detectable in gut nuclei (arrowheads).

Picture from Goh KY et al. (2018) Biochim Biophys Acta "A large transcribed enhancer region regulates C. elegans bed-3 and the ...."

(A) bed-3 is expressed in the M lineage including M descendants and SM descendants.

Picture from Yang Q et al. (2017) Dev Cell "The Invading Anchor Cell Induces Lateral Membrane Constriction during Vulval ...."

(M-P) Localization of the endogenous GFP::TOCA-1 reporter zh110 in wild-type (M) and unc-6(ev400) mutants (O and P) before (M and O) and after (N and P)lumen formation. (M') and (O') show yz projections of the lateral VulF membranes. The inset in (O) shows the displaced AC in the unc-6(ev400) mutant in a differentfocal plane.

Picture from Bender LB et al. (2006) Development "MES-4: an autosome-associated histone methyltransferase that participates in ...."

Figure S1. Comparison of the distributions of H3K36me2 and MES-4. Tissues from wild-type and mes-4 mutant adult hermaphrodites show antibody staining on the left, and on the right a merge of antibody staining (green) and DNA stained with PL4-2 (red). (A) In wild type, anti-H3K36me2 staining is in all nuclei of the germ line, and also in somatic gut nuclei (arrowheads). Arrows in A and B indicate the start of the transition zone. (B) In a wild-type germ line, the MES-4 pattern is dynamic (Fong et al., 2002). MES-4 levels are highest in the distal mitotic region, drop to nearly undetectable levels at the transition zone, rise modestly during late pachytene, and become markedly enhanced after fertilization (see early embryos in the upper half of panel). MES-4 is not detectable in gut nuclei (arrowheads). (C) In a mes-4(bn23) M+Z- hermaphrodite stained with the antibody against MES-4 fusion protein, MES-4 is undetectable in the distal mitotic region of the germ line. bn23 is a protein-null allele. Scale bar: 20 μm for A,B; 10 μm, for C.

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).

Picture from Hashimshony T et al. (2015) Nature "Spatiotemporal transcriptomics reveals the evolutionary history of the ...."

2. Hashimshony, T., Feder, M., Levin, M., Hall, B. K. & Yanai, I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519, 219-22 (2014).