Picture from Bandyopadhyay J et al. (2002) Mol Biol Cell "Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is ...."

CNB-1::GFP expresses in spermatheca (C; arrowhead) and intestine (C; arrow). Nerve cord expression can also be observed in this image.

Picture from Geisler F et al. (2016) Mol Biol Cell "A novel function for the MAP kinase SMA-5 in intestinal tube ...."

The pancytoplasmic localization of SMA-5::EGFP inthe intestine can be appreciated in B' and B'' (nuclei devoid of fluorescence marked by asterisks).

Picture from Inoue T et al. (2002) Mech Dev "Gene expression markers for Caenorhabditis elegans vulval cells."

Side-by-side comparison of markers disregarding the temporal aspect,demonstrating that six different cell types can be distinguished based on the expression pattern.

Picture from Alexander M et al. (2009) Development "An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis ...."

(G) Functional UNC-97::GFP (Hobert et al., 1999) fusion protein can be seen in the muscle arms (red arrows). Scale bar 50 μm.

Picture from Alexander M et al. (2009) Development "An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis ...."

(F) Functional UNC-95::GFP (Broday et al., 2004) fusion protein can be seen in the muscle arms (red arrows). Scale bar 50 μm.

Picture from Au C et al. (2009) PLoS One "SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated ...."

Figure 10. Working model for Mn and Fe uptake by SMF transporters in C. elegans.A: Regulation of Mn, Fe contents and SMF transporters upon low Mn exposure (0.001 mM to 3 mM), which is believed to be beneficial for the worm physiology [92]. B: Regulation of Mn, Fe contents and SMF transporters upon high Mn exposure (50 mM to 150 mM), which was shown to be toxic (Fig. 3, 4). We propose that SMF-3* is the main transporter responsible for Mn uptake (A), and that it is degraded upon exposure to high Mn concentrations (B). Since high Fe content limit Mn uptake, SMF-3 may be inhibited by intracellular Fe (A). SMF-1 would be involved in Mn uptake to a lesser extent, and together with SMF-2*, would be responsible for Fe uptake. Upon Low Mn exposure SMF-2 would be mostly required for Fe uptake (A), whereas upon high Mn exposure, SMF-2 would be inhibited and SMF-1 would partially compensate for Fe uptake (B). In the case of SMF-2 and SMF-1, metal uptake could essentially take place in acidified endosomal compartments, as SMF-2 is mainly cytoplasmic and SMF-1 is detected in sub-apical compartments. Gap-junction communications between pharyngeal epithelia, vpi cells and intestinal cells permit Mn2+ and Fe2+ to diffuse distant from their site of uptake, allowing metal-dependent regulation of smf mRNA stability or transcription. A prediction of our model is that the Fe gradient established by SMF-2 activity would be reversed upon high Mn exposure (B), and could constitute the signal for smf expression regulation. Since basal smf mRNA levels depend on the integrity of each smf genomic sequence (Fig. 9), transcriptions of smf genes are assumed to be interdependent, maybe because they require a common transcription factor. * SMF-2 might transport Mn and SMF-3 might transport Fe, but these possibilities are not explored in this model. The size of the text reflects the concentration of the species.

Picture from Pasierbek P et al. (2001) Genes Dev "A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome ...."

REC-8 can not be detected in embryos (C). It is homogeneously distributed in early nuclei of the gonad (F) and is condensed into threads in pachytene nuclei (J).

Picture from Blanchette CR et al. (2015) PLoS Biol "Glypican Is a Modulator of Netrin-Mediated Axon Guidance."

Fig 3. unc-6/netrin signaling via the unc-5/UNC5 receptor requires lon-2/glypican. (A) The axon of PVM normally migrates ventrally in the wild type, but it can be forced to migrate dorsally by misexpressing the repulsive receptor unc-5/UNC5. We quantified PVM since AVM could not be reliably identified (bothAVM and neighboring ALMR axons project dorsally in Pmec-7::unc-5 transgenic animals.)

Picture from Deplancke B et al. (2006) Cell "A gene-centered C. elegans protein-DNA interaction network."

(C) PJC8.6::JC8.6:::GFP - Mosaic animals, no stable transgenic line could be obtained. GFP is broadly expressed in embryos, larvae and adults with strongest GFP expression in the pharynx and vulva.

Picture from Kato M et al. (2009) Development "The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program ...."

(G,H) Confocal image of L4 stage male posterior body and a high-magnification image of LC show MIG-2::GFP to be membrane localized to the ventral, adherent side (arrow).