Picture from Coleman-Hulbert, Anna L. et al. MicroPubl Biol

Longevity under adult β-guanidinopropionic acid exposure: Survival curves for C. elegans strain N2, C. briggsae strain AF16, and C. tropicalis strain JU1373 exposed to β-guanidinopropionic acid at various concentrations starting on the first day of adulthood. Only the lifespan of AF16 at 300 mM (mean=26.2 days, p=0.0123) differed significantly from the control (mean=31.5 days for AF16; control means for N2=18.8 days and JU1373=25.1 days; statistical comparisons were made with a Cox proportional hazards mixed-model using the coxme v.2.2-5 package in R (Therneau 2012; Lucanic et al. 2017)).

Picture from Coleman-Hulbert, Anna L. et al. MicroPubl Biol

Figure 1. Longevity under adult imatinib mesylate exposure. Survival curves for C. elegans strain N2, C. briggsae strain AF16, and C. tropicalis strain JU1373 exposed to imatinib mesylate at various concentrations starting on day one of adulthood. Each line represents three technical replicates of 50 animals each. Mean lifespan of N2 on 1000 µM (mean=7.6 days, p<1e-04), AF16 on 50 µM (mean=29 days, p=0.0284), 500 µM (mean=25.6 days, p<1e-04), and 1000 µM (mean=24.9 days, p<1e-04), and JU1373 on 50 µM (mean=23.6 days, p=0.0361) differed significantly from the control (mean=18.5 days for N2, 32.1 days for AF16, 25.2 days for JU1373; Cox proportional hazard mixed-model using the coxme v.2.2-5 package in R (Therneau 2012)).