Picture from Mok DZ et al. (2015) BMC Dev Biol "Morphologically defined sub-stages of C. elegans vulval development in the ...."

L4.6: ventrally oriented "fingers" are indicated by black arrows.

Picture from Mok DZ et al. (2015) BMC Dev Biol "Morphologically defined sub-stages of C. elegans vulval development in the ...."

L4.9: the vulval lumen (black arrow) collapses during these stage.

Picture from Mok DZ et al. (2015) BMC Dev Biol "Morphologically defined sub-stages of C. elegans vulval development in the ...."

L4.8: the vulval lumen (black arrow) collapses during these stage.

Picture from Mok DZ et al. (2015) BMC Dev Biol "Morphologically defined sub-stages of C. elegans vulval development in the ...."

L4.5: the concave curve between vulD and vulB2 is shown (black arc).

Picture from Hermann GJ et al. (2012) PLoS One "C. elegans BLOC-1 functions in trafficking to lysosome-related gut ...."

Figure 9. Analysis of CDF-2::GFP trafficking. In wild type, CDF-2::GFP (black arrows) colocalized with PGP-2 on gut granules (A-C) and CDF- 2::GFP (black arrows) was not associated with F11E6.1::mCherry containing conventional lysosomes (white arrows) (G-I). (D-F) CDF-2::GFP was associated with PGP-2 containing gut granules (black arrows) and apical compartments (white arrows) in an AP-3 mutant. (J-L) PGP-2 was lacking and CDF-2::GFP was localized to conventional lysosomes (black arrows) and the plasma membrane (white arrowhead) in glo-2(zu455). In all panels, black arrowheads flank the intestine of 1.5-fold stage embryos.

Picture from Hermann GJ et al. (2012) PLoS One "C. elegans BLOC-1 functions in trafficking to lysosome-related gut ...."

Figure 6. Analysis of LMP-1 trafficking. (A-C) In intestinal cells LMP-1::GFP localized to the basolateral plasma membrane (white arrow) and apically enriched organelles (black arrow) that did not overlap with PGP-2 containing gut granules (white arrowhead). (D-F) Endogenous LMP-1 localized to apical CNTS-1::GFP containing conventional lysosomes (white arrows) and more basally localized compartments (black arrow) lacking CNTS-1::GFP. (G-I) In the basal region of the intestine, LMP-1 localized to PGP-2 containing gut granules (black arrows). (J-L) In a mutant lacking AP-3 function, gut granules containing PGP-2 (white arrowhead) lacked LMP-1, which was restricted to apical compartments (black arrows). (M-O) PGP-2 containing organelles were lacking in glo-2(zu455) embryos and LMP-1 was enriched on apically localized organelles (black arrows). In all panels, black arrowheads flank the intestine. In A-C a pretzel stage embryo and in D-O 1.5-fold stage embryos are shown.

Picture from Hermann GJ et al. (2012) PLoS One "C. elegans BLOC-1 functions in trafficking to lysosome-related gut ...."

(A-C) In intestinal cells LMP-1::GFP localized to the basolateral plasma membrane (white arrow) and apically enriched organelles (black arrow) that did not overlap with PGP-2 containing gut granules (white arrowhead). (D-F) Endogenous LMP-1 localized to apical CNTS-1::GFP containing conventional lysosomes (white arrows) and more basally localized compartments (black arrow) lacking CNTS-1::GFP. (G-I) In the basal region of the intestine, LMP-1 localized to PGP-2 containing gut granules (black arrows).

Picture from Liegeois S et al. (2006) J Cell Biol "The V0-ATPase mediates apical secretion of exosomes containing ...."

(A) Immunogold staining using a VHA-5 antiserum in wild- type adults. (A1 and A2) Gold beads were frequently observed in the cuticle (white arrowheads) and at the apical plasma membrane (filled black arrowheads); note that we could occasionally find vesicle-like bead-bound particles in the cuticle (A2). (A3 and A4) High-magnification pictures of light (A3) and dense (A4) MVBs. White arrowheads, cuticular staining; black arrowheads, apical membrane staining; empty white arrowheads, intraorganelle staining; empty black arrowhead, cytosolic or background staining. Note that gold beads could be seen within MVB intralumenal vesicles, and at the MVB limiting membrane.

Picture from Zhang Y et al. (2013) BMC Genomics "Comparative genomics and functional study of lipid metabolic genes in ...."

Figure 2. Lipid metabolism pathways in C. elegans. 16 lipid metabolism pathways are integrated into a lipid metabolism network. Genes were colored based on their data resources (see Figure 1). Black arrows linked different substrates. Two continuous black arrows indicate that there are more than two reactions. The dashed green arrow was used to link different pathways. The Green circle surround linked the pathway name.

Picture from Mok DZ et al. (2015) BMC Dev Biol "Morphologically defined sub-stages of C. elegans vulval development in the ...."

L4.4: the utse cell separating the vulva lumen from the uterine lumen is indicated by the white arrow. Black arrows point to "fingers" which form on sides of the vulva.