excess intestinal cells

Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage.

E lineage variant

The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals.

M lineage variant

The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage.

no Intestine

Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells.

cell cycle arrest

Cells of the animals cease during one of its replicative phases (G1, S, G2, M).

early exit cell cycle

Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells.

male M lineage variant

The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals.

population fitness phenotype

Populations exhibit variations in the ability to survive, grow and reproduce, thus affecting the contribution to the gene pool over generations compared to control populations. In C. elegans the fitness of a population can by assessed by measuring the rate at which E. coli is consumed.

G2 checkpoint variant

Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells.

hermaphrodite sex muscle morphology variant

Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas).