Hajnal A (2002) Mol Cell "Fine-tuning the RAS signaling pathway: Zn(2+) makes the difference."

Hajnal A

[Mol Cell, 2002]

In the May, 2002 issue of Developmental Cell, Bruinsma et al. report that the CDF-1 cation diffusion facilitator protein is required for efficient Ras-mediated signaling in C. elegans. CDF-1 reduces intracellular Zn(2+) levels, indicating an inhibitory effect of Zn(2+) on the Ras pathway.