Shemesh N et al. (2018) Mol Cell "No Excess Baggage: New Life Starts with a Clean Slate."

Ben-Zvi A, Shemesh N

[Mol Cell, 2018]

A new mechanism for clearing protein damage from maturing oocytes has been described in a recent study by Bohnert and Kenyon (2017), who demonstrated that sperm-secreted hormones activate a vascular H⁺-ATPase pump that acidifies lysosomes and thus restores protein homeostasis.

Dawes HE et al. (1999) Science "Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate."

Nusbaum C, Meyer BJ, Dawes HE, Davis TL, Matsubara Lapidus D, Berlin DS

[Science, 1999]

In many organisms, master control genes coordinately regulate sex-specific aspects of development. SDC-2 was shown to induce hermaphrodite sexual differentiation and activate X chromosome dosage compensation in Caenorhabditis elegans. To control these distinct processes, SDC-2 acts as a strong gene-specific repressor and a weaker chromosome-wide repressor. To initiate hermaphrodite development, SDC-2 associates with the promoter of the male sex-determining gene her-1 to repress its transcription. To activate dosage compensation, SDC-2 triggers assembly of a specialized protein complex exclusively on hermaphrodite X chromosomes to reduce gene expression by half. SDC-2 can localize to X chromosomes without other components of the dosage compensation complex, suggesting that SDC-2 targets dosage compensation machinery to X chromosomes.AD - Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA.FAU - Dawes, H EAU - Dawes HEFAU - Berlin, D SAU - Berlin DSFAU - Lapidus, D MAU - Lapidus DMFAU - Nusbaum, CAU - Nusbaum CFAU - Davis, T LAU - Davis TLFAU - Meyer, B JAU - Meyer BJLA - engSI - GENBANK/AF111934ID - GM30702/GM/NIGMSID - T32 GM07127/GM/NIGMSPT - Journal ArticleCY - UNITED STATESTA - ScienceJID - 0404511RN - 0 (Helminth Proteins)RN - 0 (Repressor Proteins)RN - 0 (Sdc-3 protein)RN - 0 (her-1 protein)SB - IM