[
Genome Res,
1996]
If world oil prices dropped to zero next year, how would it change the world economy? Investments in oil field exploration would lose their value overnight, whereas shares in a factory making environmentally friendly combustion engines might go up. Everybody would feel the need to plan ahead, and many plans would change. In genetics and molecular biology, DNA sequences are the fuel of research, and their prices are falling dramatically. Within 5 years many complete genomes will be sequenced, and sequence data will be like tap water in Amsterdam-essential for life, but too cheap to measure. A project that was perfectly rational 2 years ago will be a total waste of time tomorrow, and projects that seemed impossible will become feasible. The aim of this review is to explore the consequences for biology of the wealth of DNA sequence data now becoming available. Several bacterial genomes have been sequenced already (Fleischmann et al. 1995; Fraser et al. 1995). The first animal to feel these changes will be the nematode Caenorhabditis elegans, and the worm" will be the focus of this review. The virtues of C. elegans as a model system in biology have recently been sung elsewhere (Hodgkin et al. 1995). In brief, it does everything that makes life interesting (eating, copulating, getting around, and relating to the environment) and manages to do so with only 959 cells, of which 302 form the brain. However, it is likely that much of what is said will apply equally to other species; thus, I hope that the review may also be of some interest outside of the C. elegans community.
[
Front Cell Dev Biol,
2023]
The mitochondrial unfolded protein response (UPR<sup>mt</sup>) is a stress response pathway that regulates the expression of mitochondrial chaperones, proteases, and other proteins involved in protein folding and degradation, thereby ensuring proper mitochondrial function. In addition to this critical function, the UPR<sup>mt</sup> also plays a role in other cellular processes such as mitochondrial biogenesis, energy metabolism, and cellular signaling. Moreover, the UPR<sup>mt</sup> is strongly associated with various diseases. From 2004 to 2022, there has been a lot of interest in UPR<sup>mt</sup>. The present study aims to utilized bibliometric tools to assess the genesis, current areas of focus, and research trends pertaining to UPR<sup>mt</sup>, thereby highlighting avenues for future research. There were 442 papers discovered to be related to UPR<sup>mt</sup>, with the overall number of publications rising yearly. <i>International Journal of Molecular Sciences</i> was the most prominent journal in this field. 2421 authors from 1,402 institutions in 184 nations published studies on UPR<sup>mt</sup>. The United States was the most productive country (197 documents). The top three authors were Johan Auwerx, Cole M Haynes, and Dongryeol Ryu. The early focus of UPR<sup>mt</sup> is "protein." And then the UPR<sup>mt</sup> research shifted from <i>Caenorhabditis elegans</i> back to mammals, and its close link to aging and various diseases. The top emerging research hotspots are neurodegenerative diseases and metabolic diseases. These findings provide the trends and frontiers in the field of UPR<sup>mt</sup>, and valuable information for clinicians and scientists to identify new perspectives with potential collaborators and cooperative countries.