Hofmann ER et al. (2000) Cold Spring Harb Symp Quant Biol "DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans."

Milstein S, Hengartner MO, Hofmann ER

[Cold Spring Harb Symp Quant Biol, 2000]

Genomic instability is believed to be an enabling characteristic of cancer (Hanahan and Weinberg 2000). Therefore, it is not surprising that sophisticated mechanisms exist to maintain the integrity of the genome. Damage to DNA triggers checkpoint controls that result in cell cycle arrest and repair of the lesion (Nurse, 1997, 2000; Weinert 1998). In multicellular organisms, when DNA damage is extensive, these potentially harmful cells are eliminated by apoptosis (Enoch and Norbury 1995; Evan and Littlewood 1998)...