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MicroPubl Biol,
2022]
A complex series of interconnected events during meiotic prophase creates the physical connections between homologous chromosomes essential to ensure their proper partitioning during the first meiotic division. HIM-19 is an important factor that regulates meiotic prophase progression in C. elegans , but its molecular function(s) and localization have remained unclear. We show here that tagged HIM-19 expressed from its endogenous locus exhibits dynamic localization in germ cell nuclei that support its proposed role as a regulator of the CHK-2 protein kinase.