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[
European Worm Meeting,
2002]
Cilia are evolutionarily conserved subcellular organelles functioning in cell motility, movement of extracellular fluids, sensory perception (e.g. smell) and determination of left-right asymmetry. While a great deal is known about the structure, function and motility of cilia, very little is known about the molecular mechanisms that regulate ciliogenesis in a cell-type specific and developmental manner. How do cilia become functional? How can they do what they do?
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[
East Afr Med J,
1995]
Onchocerciasis affects 7% of Uganda's population and 1.5 million more people are at risk of infection with Onchocerca volvulus, the nematode that causes the disease. This paper reports the results of part of a multi-centre study whose objective was to determine the prevalence of onchocercal skin disease and its associated psychosocial importance in Uganda. The study employed a standardised clinical dermatological survey method along with the use of structured questionnaires, focus group discussions and key informant interviews. Out of a total of 993 persons examined to determine the prevalence of onchocercal skin lesions 253 persons were interviewed to determine the psychosocial importance of the disease. The results indicate that onchocercal skin disease is associated with a variety of psychosocial, physical and economic effects. The disease also leads to stigmatisation of affected persons and their families. It is suggested that dermatological effects of onchocerciasis should be recognised as an important cause of morbidity in Uganda.
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[
Cell Host Microbe,
2022]
Caenorhabditis elegans do not grow on either Staphylococcus saprophyticus or heat-killed Escherichia coli, but do so when exposed to both. In this issue of Cell Host & Microbe, Geng and colleagues have identified E.coli-derived signals as well as the host's neural and innate immunity pathways that promote digestion of S.saprophyticus.
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[
Nat Methods,
2008]
We describe an automated method to isolate mutant Caenorhabditis elegans that do not appropriately execute cellular differentiation programs. We used a fluorescence-activated sorting mechanism implemented in the COPAS Biosort machine to isolate mutants with subtle alterations in the cellular specificity of GFP expression. This methodology is considerably more efficient than comparable manual screens and enabled us to isolate mutants in which dopamine neurons do not differentiate appropriately.
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[
Curr Biol,
2006]
A left-right asymmetry in neuronal function is specified surprisingly early during embryogenesis in Caenorhabditis elegans. Do early cues influence left-right asymmetries in other animals? How are early cues remembered until late in development?
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[
Curr Biol,
2010]
Why do many microRNA gene mutants display no evident phenotype? Multiply mutant worms that are selectively impaired in genetic regulatory network activities have been used to uncover previously unknown functions for numerous Caenorhabditis elegans microRNAs.
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[
Kisaengchunghak Chapchi,
1966]
The clinical manifestations in filarial infection were examined during 1965-1966 from the known endemic areas: Yongju, a mountainous inland area and Cheju-Do, an island. 1. All the microfilaria which were found during the survey were Brugia malayi. 2. The principal symptom was cuticular hypertrophy (elephantiasis). It was found in 4 cases from Yongju among 707 villagers, 84 cases from Cheju-Do among 2,376 villagers. 3. Four microfilaremia cases (4.5%) were found among a total of 88 cases of elephantiasis. 4. In Cheju-Do, the higher incidence of elephantiasis was observed among people over 20 years old and the females showed much higher incidence than males (30 males and 54 females). 5. The cuticular hypertrophic changes (elephantiasis) appeared more often in the lower extremities(77%) than in the upper part of the body, and in the right side than in the left.
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[
Curr Biol,
2000]
Recent studies of vulva development in the nematode Pristionchus pacificus have identified cell interactions that do not appear to occur in Caenorhabditis elegans, The new results underscore the diversity of patterning mechanisms that can produce structures with similar cellular morphology.
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[
Curr Biol,
2001]
How do animal tissues resist the shearing forces to which they are exposed during locomotion or harsh encounters with the environment? Genetic analysis in Caenorhabditis elegans is furthering our understanding of the nature and function of the attachments that preserve tissue integrity.
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[
Cold Spring Harb Symp Quant Biol,
1982]
Microtubules (MTs) are ubiquitous components of neuronal processes, and although they have been implicated in neurite outgrowth, shape maintenance, axonal transport, and sensory transduction, their function remains unclear. The MTs in the neurons of the nematode Caenorhabditis elegans have unusual structures that permit a comparative approach to the relationship of microtubule structure and function. A set of six touch-receptor neurons (the microtubule cells) contain prominent arrays of large MTs. These MTs have more protofilaments than do MTs in other neurons (15 as opposed to 11), and they respond differently to antimicrotubule drugs, fixation protocols, temperature, and mutation. Studies of C. elegans neurotubules suggest that most MT functions do not require long, continuous MTs or MTs with a specific number of protofilaments. Some functions, however, such as the sensory transduction of the microtubule cells, do require a specific microtubule substructure. A review of these data is presented in this