Sumino Yanase et al. (2008) C.elegans Aging, Stress, Pathogenesis, and Heterochrony Meeting "sod-5; A target gene of DAF-16 transcription factor in Caenorhabditis elegans"

Yoshihiro Takahashi, Sumino Yanase, Naohiro Suga, Naoaki Ishii

[C.elegans Aging, Stress, Pathogenesis, and Heterochrony Meeting, 2008]

We now report that a DAF-16 consensus binding element (DBE) sequence, which binds the DAF-16 transcription factor, was discovered in the promoter region of sod-5 gene encoding a Cu/Zn superoxide dismutase (SOD) in the nematode Caenorhabditis elegans (C. elegans). DAF-16 transcription factor is related to regulation of normal aging and oxidative stress resistance. The DBE position was 192 base pairs (bp) upstream of the start site for the transcription. In a daf-16 gene null mutant, daf-16(mgDf50) strain, the sod-5 gene expression as well as sod-3 gene was obviously suppressed compared with it in wild-type N2. In addition, the phenotype of lifespan in daf-16(mgDf50) animals was reduced when compared with N2 during normal aging.