Felix MA et al. (2002) Hermann, Editeurs des Sciences et des Arts. Paris, France. "Caenorhabditis elegans. Un organisme modele en biologie."

Labouesse M, Segalat L, Felix MA

[Hermann, Editeurs des Sciences et des Arts. Paris, France., 2002]

L'espce Caenorhabditis elegans fut dcrite en 1900 Alger par E. Maupas, qui s'intressait son mode de reproduction hermaphrodite. Plus tard, vers le milieu du vingtime sicle, V. Nigon et ses collaboratuers Lyon tudirent les reorganizations cellulaires accompagnant la fecundation et les premiers clivages. J. Brun isola les preiers mutants morpholgiques.

Ebrahimi FAW et al. (1998) Curr Biol "Olfactory G proteins: Simple and complex signal transduction."

Ebrahimi FAW, Chess A

[Curr Biol, 1998]

In both vertebrates and invertebrates, olfactory perception is mediated by G-protein-coupled receptors. Recent work, in both mouse and Caenorhabditis elegans, sheds light on the role of specific G proteins in olfactory signal transduction, neuronal morphology and axon guidance.

Sigurbjornsdottir S et al. (2014) Nat Rev Mol Cell Biol "Molecular mechanisms of de novo lumen formation."

Mathew R, Sigurbjornsdottir S, Leptin M

[Nat Rev Mol Cell Biol, 2014]

Many organs contain networks of epithelial tubes that transport gases or fluids. A lumen can be generated by tissue that enwraps a pre-existing extracellular space or it can arise de novo either between cells or within a single cell in a position where there was no space previously. Apparently distinct mechanisms of de novo lumen formation observed in vitro - in three-dimensional cultures of endothelial and Madin-Darby canine kidney (MDCK) cells - and in vivo - in zebrafish vasculature, Caenorhabditis elegans excretory cells and the Drosophila melanogaster trachea - in fact share many common features. In all systems, lumen formation involves the structured expansion of the apical plasma membrane through general mechanisms of vesicle transport and of microtubule and actin cytoskeleton regulation.

Ishii N et al. (2000) Results Probl Cell Differ "Oxidative stress and aging in Caenorhabditis elegans."

Ishii N, Hartman PS

[Results Probl Cell Differ, 2000]

Aging is controlled by a complex interplay of both genetic and environmental factors. Because of this, many theories have been advanced that seek to explain the etiology of both cellular and organismal aging. In some cases, these theories are not mutually exclusive...

Thomas JH (1998) Cell "Social life and the single nucleotide: foraging behavior in C. elegans."

Thomas JH

[Cell, 1998]

Since the rise of the field of sociobiology, the study of the biological basis of social behavior, scientists have striven to assign genetic origins for a variety of social behaviors. There have been a number of highly publicized and often controversial studies of the basis of human social behavoirs such as sexual orientation and religion. Less trumpeted by the popular press, there have been a number of more credible advances in the genetic analysis of complex behavioral traits. Two papers in the past year, one in this issue of Cell (de Bono and Bargmann, 1998), have established two interesting cases of a molecular basis for complex behaviors that are arguably relevant to social interactions in natural populations. Both have to do with food foraging strategies, one in Drosophila and one in C.

Thor S et al. (2002) Curr Opin Genet Dev "Motor neuron specification in worms, flies and mice: conserved and 'lost' mechanisms."

Thor S, Thomas JB

[Curr Opin Genet Dev, 2002]

Motor neuron differentiation has been studied intensively in both invertebrates and vertebrates in recent years. These studies have led to the identification of several key regulatory genes acting to generate motor neurons and to specify their subclass identities. By comparing findings from Caenorhabditis elegans, Drosophila and vertebrate model systems, it is apparent that both evolutionarily conserved and non-conserved mechanisms are used.

Penninger JM et al. (2003) Nature Cell Biology "Mitochondria, AIF and caspases - rivaling for cell death execution."

Penninger JM, Kroemer G

[Nature Cell Biology, 2003]

In both the nematode Caenorhabditis elegans and mammals, two proteins released from the mitochondrion - apoptosis inducing factor (AIF) and endonuclease G - cooperate in executing programmed cell death. Although both factors can kill cells in a caspase-independent fashion, new studies indicate that their translocation from mitochondria depends, in part, on caspase activation. Together, these data raise new questions about the functional hierarchy between caspases, AIF and mitochondrial membrane

Qu H et al. (2021) Eur J Med Chem "A novel small-molecule fatty acid synthase inhibitor with antitumor activity by cell cycle arrest and cell division inhibition."

Qi Y, Cui J, Wang R, Tang C, Shan K, Feng N, Cui G, Chen YQ, Qu H, Fu G, Li J

[Eur J Med Chem, 2021]

Fatty acid synthase (FASN), the key enzyme in de novo lipogenesis, is an attractive therapeutic target for diseases characterized by excessive lipid accumulation. Many FASN inhibitors have failed in the clinical trial phase, largely because of poor solubility and safety. In this study, we generated a novel small-molecule FASN inhibitor by structure-based virtual screening. PFI09, the lead compound, is easy to synthesize, and inhibits the lipid synthesis in OP9 mammalian cell line and Caenorhabditis elegans as well as the proliferation of several cancer cell lines via the blockade of FASN. Mechanistic investigations show that PFI09 induces S-phase arrest, cell division reduction and apoptosis. We also develop a chemically stable analog of PFI09, MFI03, which reduces the proliferation of PC3 tumor cells both invitro and invivo, without toxicity to mice. In summary, our data suggest that MFI03 is an effective FASN inhibitor and a promising antineoplastic drug candidate.

Wade N (1998) The New York Times "Animal's genetic program decoded, in a science first."

Wade N

[The New York Times, 1998]

Biologists have for the first time deciphered the full genetic programming of an animal, a landmark achievement both in its own right and as a milestone toward understanding the human genome.

Kenyon CJ (1985) Philos Trans R Soc Lond B Biol Sci "Cell lineage and the control of C. elegans development."

Kenyon CJ

[Philos Trans R Soc Lond B Biol Sci, 1985]

This paper provides a brief summary of the Caenorhabditis elegans cell lineage, the evidence for both intrinsic and extrinsic cell specification, and experiments that suggest mechanisms for cell differentiation and patterning.