Platzer U et al. (2004) Int Rev Cytol "Genetic networks in the early development of Caenorhabditis elegans."

Meinzer HP, Platzer U

[Int Rev Cytol, 2004]

One of the best-studied model organisms in biology is Caenorhabditis elegans. Because of its simple architecture and other biological advantages, considerable data have been collected about the regulation of its development. In this review, currently available data concerning the early phase of embryonic development are presented in the form of genetic networks. We performed computer simulations of regulatory mechanisms in embryonic development, and the results are described and compared with experimental observations.

Denzel MS et al. (2015) Curr Opin Cell Biol "Hexosamine pathway and (ER) protein quality control."

Antebi A, Denzel MS

[Curr Opin Cell Biol, 2015]

Aminosugars produced in the hexosamine pathway (HP) are utilized in protein glycosylation reactions involved in protein maturation and cellular signaling. Recent evidence revealed a role of the HP in protein quality control and ageing. Elevation of the HP product UDP-N-acetylglucosamine in the nematode Caenorhabditis elegans results in resistance towards toxic aggregation-prone proteins, and extended lifespan. Glutamine-fructose 6 phosphate aminotransferase (GFAT-1), the HP's key enzyme, is a target of the unfolded protein response (UPR). Thus, cardiac stress in mice results in GFAT-1 activation that triggers a cytoprotective response. Feeding of glucosamine to aged mice increases their life expectancy. Here we discuss HP activation and cellular protein quality control mechanisms that result in stress resistance and suppression of age-related proteotoxicity.