[
Worm Breeder's Gazette,
1998]
TOR (target of rapamycin) belongs to a family of proteins which has a carboxy-terminal domain similar to catalytic domains of lipid kinases. Members of this family (ATM-like proteins: MEC1, TEL1, RAD3, MEI-41, ATM, DNA-PK and TOR) are involved in cell-cycle regulation, DNA repair and recombination. TOR proteins were first discovered in yeast (TOR1 and TOR2) and homologs have now been found in mammals (FRAP/RAFT1/RAPT1/mTOR). None of these proteins seem to have a lipid kinase activity, but for some a protein kinase activity has been shown.