I plan to have an updated genetic map (suitable for framing) ready for distribution at the C. elegans Meeting. Since I would like to make it as complete as possible, I hereby solicit all unpublished data pertaining to the map. (Indeed, I m always happy to receive preprints and reprints as well.) For inclusion in this revision, please send me your data before March 1--the earlier the better.

White J (2018) Development "Obituary: John Sulston (1942-2018)."

White J

[

Development,

2018]

John Sulston, a pioneer in the developmental studies of the nematode C. elegans who went on to spearhead the sequencing of the genome of this organism and ultimately the human genome, died on 6th March 2018, shortly after being diagnosed with stomach cancer. Here, I reflect on John's life and work, with a particular focus on his time working on the developmental genetics and lineage of C. elegans.

Vrablik TL et al. (2012) Genes Dev "Emerging roles for specific fatty acids in developmental processes."

Vrablik TL, Watts JL

[

Genes Dev,

2012]

Animals synthesize a vast range of fatty acids serving diverse cellular functions. The roles of specific fatty acids in early development are just beginning to be characterized. In the March 15, 2012, issue of Genes & Development, Kniazeva and colleagues (pp. 554-566) describe how the particular combination of a branched chain fatty acid and an acyl-CoA synthetase is required for critical cellular processes during early embryogenesis in Caenorhabditis elegans.

Goldstein B et al. (2009) Development "Shape meets polarity in Japan."

Hamada H, Goldstein B

[

Development,

2009]

A diverse group of developmental biologists who study cell polarity gathered in late March 2009 at the RIKEN Center for Developmental Biology in Kobe, Japan, for a symposium entitled ;Shape and Polarity''. The organizers, Masatoshi Takeichi, Fumio Matsuzaki, Hitoshi Sawa [RIKEN Center for Developmental Biology (CDB), Kobe, Japan] and Carl-Philipp Heisenberg (Max Planck Institute, Dresden, Germany), put together an engaging program that highlighted recent progress towards understanding the mechanisms of cell polarization during development, and the functions of cell polarity in shaping development.

Mary Ann Tuli et al. (2005) International Worm Meeting "CGC and WormBase"

Theresa Stiernagle, Robert Herman, Jonathan Hodgkin, Richard Durbin, Mary Ann Tuli

[

International Worm Meeting,

2005]

WormBase is an international consortium of biologists and computer scientists from Caltech (USA), Cold Spring Harbour Laboratory (USA), Wellcome Trust Sanger Institute (UK) and the Genome Sequencing Center at Washington University (USA). WormBase is dedicated to providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C.elegans and some related nematodes. WormBase can be freely accessed at www.wormbase.org and is also available for download at ftp://ftp.wormbase.org/pub/wormbase/. A new database release is produced every three weeks. The UK WormBase group works closely with the Caenorhabditis Genetics Center (CGC) to curate genetic nomenclature and maintain the C.elegans genetic map. Detailed guidelines are accessible via http://www.cbs.umn.edu/CGC/Nomenclature/nomenguid.htm Since WS126 (June 2004) all CDSs, transcripts and pseudogenes have been assigned an identifier of the form WBGene00000001. This identifier is unique and remains stable when the gene object is updated. Release WS140 (March 2005) contains 44107 WBGeneIDs of which 24506 are from C.elegans, and 19587 from C.briggsae. The number of CDS objects which have been assigned a CGC approved gene name is 5707. In release WS140 (March 2005) the Variation class was introduced as a more efficient way to handle most of what was in the Allele and Locus classes. The Variation class incorporates the following: Alleles, SNPs (both confirmed and predicted), RFLPs and transposon insertions. Curation of allele data by WormBase biologists is an ongoing project and recent efforts have seen the number of Allele objects in the database increase from about 9000 in WS110 (October 2003) to about 11200 in WS140 (March 2005). Allele information is either captured from scientific journals or submitted directly by researchers using the WormBase submission forms at http://wormbase.org/db/curate/base WormBase is supported by a grant from the National Human Genomes Reseach Institute at the US National Institute of Health #P41 HG02223 and the British Medical Research Council. CGC is supported by NIH NCRR.

Shen P et al. (2017) Annu Rev Food Sci Technol "Caenorhabditis elegans: A Convenient In Vivo Model for Assessing the Impact of Food Bioactive Components on Obesity, Aging, and Alzheimer's Disease."

Zheng J, Shen P, Yue Y, Park Y

[

Annu Rev Food Sci Technol,

2017]

Caenorhabditis elegans is a small free-living nematode that lives in temperate soil environments. It has been widely employed as an animal model in research involving obesity, aging, and neurodegenerative diseases, including Alzheimer's disease, because of its various advantages, such as small size, large number of progeny production, completely sequenced genome, and short life span, over traditional animal models of vertebrates. These benefits contribute to an ideal research model organism. In this review, we provide an introduction to C. elegans and its applications in obesity, aging, and Alzheimer's disease studies, with the aim of stimulating scientists to use C. elegans as an experimental model in various fields of research. Expected final online publication date for the Annual Review of Food Science and Technology Volume 9 is March 25, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Shintoku Y et al. (2005) J Parasitol "Strongyloides ratti infection in the large intestine of wild rats, Rattus norvegicus."

Kimura E, Hasegawa H, Shintoku Y, Kondo S, Islam MZ, Kadosaka T, Itoh M

[

J Parasitol,

2005]

The large intestine of a rat has been neglected almost completely as a site of Strongyloides sp. infection. We reported that adult Strongyloides ratti remained in the large intestine for more than 80 days, producing more number of infective larvae than small intestine adults, and therefore hypothesized that parasitism in this site could be a survival strategy. In wild rats, however, no study has focused on large intestine infections of Strongyloides. The present study revealed that 32.4% of 68 wild rats, Rattus norvegicus, had the infection of S. ratti in the large intestine, with an average of 4.7 worms. These worms harbored normal eggs in the uterus. In a laboratory experiment with S. ratti and Wister rats, daily output of infective larvae by 4.7 females in the large intestine was estimated to be 4,638.4, suggesting that a few parasites could play a role in the parasite transmission. Five species of nematode found in the wild rats showed seasonality in infection intensity, with highest intensities in March-May. The number of S. ratti in the large intestine was also highest in these months.

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