Roush W (1997) Science "Worm longevity gene cloned."

Roush W

[Science, 1997]

A gene that helps control the life-span of the nematode C. elegans encodes the worm version of the insulin receptor, thereby providing a possible link between aging and glucose metabolism.

Han X et al. (2010) Nat Cell Biol "Meiotic kinetochores get pushed aside by a CLS act."

Srayko M, Han X

[Nat Cell Biol, 2010]

Kinetochores link microtubules to DNA and provide force critical for chromosome segregation in mitosis. New data show that kinetochores are not necessary for acentrosomal meiotic chromosome segregation in Caenorhabditis elegans. Instead, CLS-2 (CLASP) generates a mid-zone bundle of microtubules that are suggested to act in pushing the chromosomes apart.

Van der Bliek AM (2005) Nat Cell Biol "A sixth sense for Rab5."

Van der Bliek AM

[Nat Cell Biol, 2005]

It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.