<b/> Pomegranate juice with a high content of polyphenols, pomegranate extract, ellagic acid, and urolithin A, have anti-oxidant and anti-obesity effects in humans. Pomegranate juice extends lifespan of <i>Drosophila melanogaster</i>. <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) (n = 6) compared to the control group in each treatment, lifespan was increased by pomegranate juice in wild type (N2, 56 %, P < 0.001) and <i>
daf-16</i> mutant (<i>
daf-16(mgDf50)I</i>) (18 %, P = 0.00012), by pomegranate extract in N2 (28 %, P = 0.00004) and in <i>
daf-16(mgDf50)I</i> (10 %, P < 0.05), or by ellagic acid (11 %, P < 0.05). Pomegranate juice reduced intestinal fat deposition (IFD) in <i>C. elegans</i> (n = 10) N2 (-68 %, P = 0.0003) or in the <i>
daf-16(mgDf50)I</i> (-33 %, P = 0.0034). The intestinal fat deposition was increased by pomegranate extract in N2 (137 %, P < 0.0138) and in <i>
daf-16(mgDf50)I</i> (26 %, P = 0.0225), by ellagic acid in N2 (66 %, P < 0.0001) and in <i>
daf-16(mgDf50)I</i> (74 %, P < 0.0001), or by urolithin A in N2 (57 %, P = 0.0039) and in <i>
daf-16(mgDf50)I</i> (43 %, P = 0.0001). These effects were partially mediated by the <i>
daf-16</i> pathway. The data may offer insights to human aging and obesity due to homology with <i>C. elegans</i>.