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Cell Metab,
2014]
One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
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Curr Biol,
2010]
Recent studies have investigated the mechanisms responsible for setting spindle length - and how spindle length changes over the course of development.
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Nat Genet,
2007]
In the nematode Caenorhabditis elegans, dosage compensation is mediated by a subtle twofold downregulation of both X chromosomes. A new study provides a significant advance in our understanding of how the X is targeted for dosage compensation and how this global regulation is integrated with regulation of the expression of each gene.
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Nature,
2003]
Understanding how we grow old is a long-sought goal. A new large-scale study of gene expression in worms allows us to glimpse the complex biochemistry of lifespan.
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Nat Cell Biol,
2004]
Why are proteins glycosylated? On the basis of new studies, I propose two models to clarify the specific functions of glycosylation in worms. The first explains how intra- and inter-cellular trafficking of an N-glycosylated disintegrin-metalloprotease guides somatic gonadal cells through their migratory route, determining the shape of an organ. The second explains how rigid coats of secreted chondroitin proteoglycans bend membranes to drive cytokinesis and epithelial invagination.
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Curr Biol,
2012]
New research reveals how the intricate repertoire of ascarosides--small molecules acting as multifaceted pheromones in the nematode worm Caenorhabditis elegans--has evolved in divergent nematode taxa occupying contrasted ecological niches.
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Curr Biol,
2011]
How might the extracellular matrix contribute to cytokinesis? In a recent report, evidence is presented that the conserved extracellular matrix protein hemicentin(HIM-4) is required for cytokinesis in worms and mice.
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Nature,
1994]
On page 32 of this issue, a joint team from the Genome Sequencing Center (St. Louis, USA) and the newly founded Sanger Centre (Hinxton Hall, Cambridge, UK) report a contiguous sequence of over two megabases from chromosome III of the nematode worm, Caenorhabditis elegans. This is the longest contiguous DNA sequence yet determined, and it prompts rumination on how far we have come in the sequencing enterprise, and on how far - and where - we have
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Curr Biol,
2009]
Recent studies have demonstrated a correlation between cell size and the behaviors of the cytoskeletal division machinery during embryogenesis, giving insight into how a core cellular process is modulated over the course of development.
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Curr Biol,
2006]
A left-right asymmetry in neuronal function is specified surprisingly early during embryogenesis in Caenorhabditis elegans. Do early cues influence left-right asymmetries in other animals? How are early cues remembered until late in development?