Hoffman FM et al. (1992) Curr Opin Genet Dev "Learning about cancer through invertebrate genetics."

Sternberg PW, Hoffman FM, Herskowitz I

[Curr Opin Genet Dev, 1992]

Genetic studies in yeast, nematodes and Drosophila are revealing the signal transduction pathways that regulate differentiation and cell proliferation. Some of the critical molecules involved are homologous to proto-oncogenes and others are likely to be analogous to the products of tumor suppressor genes.