[
1974]
The free-living nematode, Caenorhaditis briggsae, is being used in our laboratory to study the complex events associated with biological aging. Our approach to this problem involved first the defining of parameters characterizing senescence in this animal, and then evaluating the effects on these aging signs of a drug reported to have a modifying effect on some aspects of the aging processes. Reference in this report to this preparation, Gerovital H3 (2% procaine hydrochloride, 0.16% benzoic acid, 0.14% potassium metabisulfite, buffered to pH 3.3 from Rom-Amer Pharmaceuticals, Ltd., Beverly Hills, California) is by its active ingredient, "Procaine".