Eddy SR (1994) Worm Breeder's Gazette "Three Families of Reverse Transcriptase Elements in C. elegans"

Eddy SR

[Worm Breeder's Gazette, 1994]

Three families of reverse transcriptase elements in C. elegans Sean Eddy, MRC-LMB, Hills Road, Cambridge CB2 2QH, UK

Kuwabara PE (1994) Worm Breeder's Gazette "Evidence For Interactions Between the Sex Determination and Dosage Compensation Pathways in the Germline"

Kuwabara PE

[Worm Breeder's Gazette, 1994]

Evidence for Interactions Between the Sex Determillation and Dosage Compensation Pathways in the Germline Patricia E. Kuwabara MRC-LMB Hills Road Cambridge CB2 2QH England

Emerson F et al. (2020) Elife "A memory of longevity."

Lee SS, Li CL, Emerson F

[Elife, 2020]

Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.

Chuang P-T et al. (1994) Worm Breeder's Gazette "DPY-27: A Protein Required For Dosage Compensation is Associated With the X Chromosome in XX Animals"

Chuang P-T, Meyer BJ, Albertson DG

[Worm Breeder's Gazette, 1994]

Dpy-27: A Protein Required for Dosage Compensation Is Associated with the X chromosome in XX Animals Pao-Tien Chuangl, Donna Albertson2 and Barbara Meyerl, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720~ and MRC Laboratory of Molecular biology, Hills Road, Cambridge, CB2 2QH UK2

Mehra A et al. (1994) Worm Breeder's Gazette "Direct Interaction Between FEM-3 and a Carboxy-Terminal Fragment of TRA-2A"

Spence AM, Heck L, Kuwabara PE, Mehra A

[Worm Breeder's Gazette, 1994]

Direct Interaction between FEM-3 and a Carboxy-Terminal Fragment Or TRA-2A Arun Mehra, Linda Heck, Patricia Kuwabara*, and Andrew Spence Dept. of Medical Genetics, University of Toronto, 1 King's College Circle, Toronto, Canada, and *MRC Laboratory of Molecular Biology, Hills Rd., Cambridge, UK

Wu Y et al. (2017) Curr Top Dev Biol "Regulation of Cell Polarity by PAR-1/MARK Kinase."

Wu Y, Griffin EE

[Curr Top Dev Biol, 2017]

PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators of cell polarity. PAR-1/MARK kinases localize and function in opposition to the anterior PAR proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In this review, we discuss the mechanisms that control the localization and activity of PAR-1/MARK kinases, including their antagonistic interactions with the anterior PAR proteins. We focus on the role PAR-1 plays in the asymmetric division of the Caenorhabditis elegans zygote, in the establishment of the anterior/posterior axis in the Drosophila oocyte and in the control of microtubule dynamics in mammalian neurons. In addition to conserved aspects of PAR-1 biology, we highlight the unique ways in which PAR-1 acts in these distinct cell types to orchestrate their polarization. Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer's disease and cancer.

Benecke M et al. (1994) Worm Breeder's Gazette "DNA Fingerprinting in C. elegans - An Approach."

Epplen JT, Schierenberg E, Benecke M

[Worm Breeder's Gazette, 1994]

DNA fingerprinting in C. elegans - an approach Mark Beneckea, Jorg T. Epplenb and Einhard Schierenberga a Zoologisches Institut der Univeritat, 50923 Koln, Germany b Ruhr-Universitat, Ab1. fur Molekulare Humangenetik, 44780 Bochum, Germany

Butkevich E et al. (2016) Sci Rep "Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking."

Grosche J, Erck C, Urlaub H, Nikolov M, Klopfenstein DR, Butkevich E, Chua JJ, Hartig W, Schmidt CF

[Sci Rep, 2016]

Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 adapter FEZ1 are enriched for presynaptic components and identify that specific phosphorylation of FEZ1 at its serine 58 regulatory site is mediated by microtubule affinity-regulating kinases (MARK/PAR-1). Loss of MARK/PAR-1 impairs axonal transport, with adapter and cargo abnormally co-aggregating in neuronal cell bodies and axons. Presynaptic specializations are markedly reduced and distorted in FEZ1 and MARK/PAR-1 mutants. Strikingly, abnormal co-aggregates of unphosphorylated FEZ1, Kinesin-1 and its putative cargoes are present in brains of transgenic mice modelling aspects of Alzheimer's disease, a neurodegenerative disorder exhibiting impaired axonal transport and altered MARK activity. Our findings suggest that perturbed FEZ1-mediated synaptic delivery of proteins arising from abnormal signalling potentially contributes to the process of neurodegeneration.

Calhoun, Adam et al. (2011) International Worm Meeting "Spatial memory in C. Elegans."

Chalasani, Sreekanth, Sharpee, Tatyana, Calhoun, Adam

[International Worm Meeting, 2011]

Worms are known to increase the frequency of turning and reversal events in response to removal of a food stimulus. This keeps the animal in a small area near the last observation of food. The increase in turning frequency is known to be regulated by dopamine and glutamate (Hills et al 2004). We have found that the search strategy is modified by the spatial pattern of food that is experienced. Worms adapt quickly to new food environments, learning spatial patterns on short timescales. The dopamine deficient cat-2 mutant is unable to learn different spatial patterns, suggesting that dopamine is required for spatial memory. References Hills T, Brockie PJ, Maricq AV (2004). Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J Neurosci 24(5): 1217-1225.

Skourti-Stathaki K et al. (2013) Mol Cell "Histone 3 s10 phosphorylation: "caught in the R loop!"."

Skourti-Stathaki K, Proudfoot NJ

[Mol Cell, 2013]

In this issue of Molecular Cell, Castellano-Pozo etal. (2013) describe a connection between R loop structures and histone 3 S10 phosphorylation (H3S10P), a mark of chromatin compaction. Their results constitute asignificant advance in our understanding of the role of R loops in genomic instability.