Golstein P (1997) Science "Controlling cell death."

Golstein P

[Science, 1997]

In many situations-both normal and pathological-cells die as a result of an orderly, stereotyped cascade of cellular events. On pages 1122, 1126, 1129, and 1132 of this issue, four reports describe the molecular basis of crucial steps in this cascade. The importance of understanding the basis of this programmed cell death was spectacularly demonstrated recently through the rescue with cell death inhibitors of mice undergoing acute liver destruction.

Goutte C (2002) Dev Cell "Genetics leads the way to the accomplices of presenilins."

Goutte C

[Dev Cell, 2002]

Presenilins mediate they-secretase cleavage of Notch transmembrane receptors as well as the transmembrane P-amyloid precursor protein (PAPP), but they are not thought to accomplish this alone. Recent genetic screens in C. elegans, presented in this issue of Developmental Cell, identify two genes that are essential to gamma-secretase activity and may interact with presenilins.

Motegi F et al. (2007) J Cell Biol "Revisiting the role of microtubules in C. elegans polarity."

Motegi F, Seydoux G

[J Cell Biol, 2007]

Cells must break symmetry to acquire polarity. Microtubules have been implicated in the induction of asymmetry in several cell types, but their role in the Caenorhabditis elegans zygote, a classic polarity model, has remained uncertain. One study (see Tsai and Ahringer on p. 397 of this issue) brings new light to this problem by demonstrating that severe loss of microtubules impairs polarity onset in C. elegans.