Fan W et al. (2015) Cell "Turning up the heat on membrane fluidity."

Fan W, Evans RM

[Cell, 2015]

How do cells maintain the fluidity of cellular membrane in response to temperature fluctuation? In this issue of Cell, Ma et al. identify a regulatory circuit involving a heat-induced acyl-CoA dehydrogenase that controls the lipid saturation level and the fluidity of cellular membranes by transcriptionally regulating a lipid desaturase.

Grishok A et al. (2000) Science "Genetic requirements for inheritance of RNAi in C. elegans."

Mello CC, Grishok A, Tabara H

[Science, 2000]

In Caenorhabditis elegans, the introduction of double-stranded RNA triggers sequence-specific genetic interference (RNAi) that is transmitted to offspring. The inheritance properties associated with this phenomenon were examined. Transmission of the interference effect occurred through a dominant extragenic agent. The wild-type activities of the RNAi pathway genes rde-1 and rde-4 were required for the formation of this interfering agent but were not needed for interference thereafter. In contrast, the rde-2 and mut-7 genes were required downstream for interference. These findings provide evidence for germ line transmission of an extragenic sequence-specific silencing factor and implicate rde-1 and rde-4 in the formation of the inherited agent.AD - Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Cancer Center, Two Biotech Suite 213, 373 Plantation Street, Worcester, MA 01605, USA.FAU - Grishok, AAU - Grishok AFAU - Tabara, HAU - Tabara HFAU - Mello, C CAU - Mello CCLA - engID - GM58800/GM/NIGMSPT - Journal ArticleCY - UNITED STATESTA - ScienceJID - 0404511RN - 0 (DNA Transposable Elements)RN - 0 (Helminth Proteins)RN - 0 (RNA, Double-Stranded)RN - 0 (RNA, Helminth)RN - 0 (rde1 protein)SB - IM