Dyczkowska, Aneta et al. (2021) International Worm Meeting "Characterizing the roles of ETS-4 transcription factor in fat metabolism"

Guo, Yanwu, Ciosk, Rafal, Dyczkowska, Aneta, Chabowska-Kita, Agnieszka

[International Worm Meeting, 2021]

Obesity is a global health problem associated with many comorbidities, sparking interest in molecular mechanisms controlling body fat. Previously, we found that fat accumulation in C. elegans requires the endoribonuclease REGE-1/Regnase-1, which inhibits the expression of transcription factor ETS-4. Analyzing gene expression dependent on ETS-4, we noticed increased expression of a peptide transporter, PEPT-1, previously implicated in fat regulation. Currently, we investigate the potential link between ETS-4 and PEPT-1-mediated fat loss, and will present our results so far.