-
[
Curr Biol,
2006]
Recent work shows that Wnt signaling directly regulates the apical constriction that drives gastrulation movements in Caenorhabditis elegans, and also promotes invagination in sea urchins, providing a novel and possibly conserved mode of developmental regulation.
-
[
Genes Dev,
2008]
Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025-1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.
-
[
Dev Cell,
2014]
Reactive oxygen species (ROS) are generated as a response to cellular stress and regulate processes including cellular signaling and wound healing. In this issue of Developmental Cell, Xu and Chisholm (2014) demonstrate that mitochondrial ROS are required for proper wound healing in Caenorhabditis elegans through controlling the redox state of actin regulators.
-
[
Curr Biol,
2011]
Recent work on a Caenorhabditis elegans transmembrane ATPase reveals a central role for the aminophospholipid phosphatidylethanolamine in the production of a class of extracellular vesicles.
-
[
Nat Cell Biol,
2011]
Aurora A kinase is a key regulator of cell division, whose functions were attributed to its ability to phosphorylate diverse substrates. Aurora A is now shown to have a kinase-independent role in the regulation of chromatin-mediated microtubule assembly.
-
[
Elife,
2015]
Chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion.
-
[
Curr Biol,
2015]
As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
-
[
Cell,
2014]
Li et al. demonstrate that a single interneuron can regulate analog- and digital-like behaviors guided by two different postsynaptic neurons. Releasing a single neurotransmitter onto downstream neurons that express receptors with distinct biophysical properties enables a small set of neurons to direct a range of functional responses.
-
[
Nat Chem Biol,
2009]
Screening a library of expressed cyclic peptides identified clones that reverse the cytotoxicity of alpha-synuclein in yeast and Caenorhabditis elegans. The results suggest a new approach for intervention in Parkinson's disease, and perhaps a druggable target.
-
[
Curr Biol,
2017]
A landmark study has revealed that an interleukin-17-like signaling system modulates a neural circuit that controls the aggregation behavior of nematodes.