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Philos Trans R Soc Lond B Biol Sci,
2018]
It has been 30 years since the 'mind of the worm' was published in <i>Philosophical Transactions B</i> (White <i>et al</i> 1986 <i>Phil. Trans. R. Soc. Lond. B</i><b>314</b>, 1-340). Predicting <i>Caenorhabditis elegans</i>' behaviour from its wiring diagram has been an enduring challenge since then. This special theme issue of <i>Philosophical Transactions B</i> combines research from neuroscientists, physicists, mathematicians and engineers to discuss advances in neural activity imaging, behaviour quantification and multiscale simulations, and how they are bringing the goal of whole-animal modelling at cellular resolution within reach.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling <i>C. elegans</i> at cellular resolution'.