Yoon JC et al. (2014) Proc Natl Acad Sci U S A "GLTSCR2/PICT1 links mitochondrial stress and Myc signaling."

Lee DY, Yoon JC, Sack LM, Steinbaugh MJ, Ling AJ, Isik M, Elledge SJ, Sinclair DA, Blackwell TK, Boduch AN

[Proc Natl Acad Sci U S A, 2014]

Mitochondrial defects underlie a multitude of human diseases. Genetic manipulation of mitochondrial regulatory pathways represents a potential therapeutic approach. We have carried out a high-throughput overexpression screen for genes that affect mitochondrial abundance or activity using flow-cytometry-based enrichment of a cell population expressing a high-complexity, concentration-normalized pool of human ORFs. The screen identified 94 candidate mitochondrial regulators including the nuclear protein GLTSCR2, also known as PICT1. GLTSCR2 enhances mitochondrial function and is required for the maintenance of oxygen consumption, consistent with a pivotal role in the control of cellular respiration. RNAi inactivation of the Caenorhabditis elegans ortholog of GLTSCR2 reduces respiration in worms, indicating functional conservation across species. GLTSCR2 controls cellular proliferation and metabolism via the transcription factor Myc, and is induced by mitochondrial stress, suggesting it may constitute a significant component of the mitochondrial signaling pathway.

Herman RK et al. (1994) Worm Breeder's Gazette "Toward and Electronic Worm Breeder's Gazette."

Herman RK, Avery L, Stiernagle TL

[Worm Breeder's Gazette, 1994]

Toward an Electronic Worm Breeder's Gazette

Avery L et al. (1994) Worm Breeder's Gazette "M3 is an Inhibitory Glutamatergic Pharyngeal Motoneuron."

Avery L, Dent JA, Davis MW, Hess GP, Denk W

[Worm Breeder's Gazette, 1994]

M3 is an inhibitory glutamatergic pharyngeal motoneuron.

Ferguson KC et al. (1995) Worm Breeder's Gazette "SL1 Performs An Essential Function In Early Embryogenesis."

Ferguson KC, Rothman JH, Heid PJ

[Worm Breeder's Gazette, 1995]

SL1 PERFORMS AN ESSENTIAL FUNCTION IN EARLY EMBRYOGENESIS

Morgan WR (1994) Worm Breeder's Gazette "An Electronic Discussion Group for C. elegans Researchers."

Morgan WR

[Worm Breeder's Gazette, 1994]

An Electronic Discussion Group For C. elegans Researchers

Aspbury RA et al. (1995) Biochem Soc Trans "Fatty acylation of polypeptides in the free-living nematode Caenorhabditis elegans."

Aspbury RA, Fisher MJ, Rees HH

[Biochem Soc Trans, 1995]

Modification, by the addition of lipid-derived groups, is an important determinant of the correct expression of a variety of polypeptides involved in signal transduction. Myristic and palmitic acid are the predominant fatty acids attached to proteins in eucaryotes. Myristic acid is normally linked, cotranslationally, via an amide bond to an N-terminal glycine. In contrast, palmitic acid attachment occurs post-translationally via an alkali-labile ester or thioester linkage...

Chamberlin HM et al. (1995) Worm Breeder's Gazette "lin-49, An Essential Gene Required For Normal F and U Cells."

Chamberlin HM, Sternberg PW, Baillie DL

[Worm Breeder's Gazette, 1995]

lin-49, an essential gene required for normal F and U cells

Reilly DK et al. (2019) Curr Biol "Chemical Communication: Linking Behavior and Physiology."

Reilly DK, Srinivasan J

[Curr Biol, 2019]

How does physiological state affect the reproductive behavior of an organism? Two new studies in Caenorhabditis elegans implicate an ancient serotonergic neuronal circuit in the link between these two outputs- reproductive behavior and physiology.

Tan EH et al. (2012) EMBO J "A new tumour suppressor enters the network of intestinal progenitor cell homeostasis."

Tan EH, Sansom OJ

[EMBO J, 2012]

In this issue of The EMBO Journal, Wilson et al (2012) elegantly discovered an important new axis for intestinal homeostasis and cancer, using an RNAi screen to enhance the RAS-induced multivulva (MUV) phenotype in Caenorhabditis elegans.

Takayama, Jun et al. (2021) MicroPubl Biol

Tajima, Tatsuya, Takayama, Jun, Onami, Shuichi, Nishimura, Hitoshi

[MicroPubl Biol, 2021]

Gamete fusion is a pivotal step during fertilization to create an organism of the next generation. In C. elegans, since oocytes have no thick egg coat like the zona pellucida, perhaps spermatozoa directly bind to and fuse with the oocyte plasma membrane (PM). Thus, C. elegans is an excellent model to investigate how a spermatozoon and an oocyte fuse together.