Antebi A (2007) Nature "Ageing: when less is more."

Antebi A

[Nature, 2007]

Antebi A (2005) Science "Physiology. The tick-tock of aging?"

Antebi A

[Science, 2005]

Antebi A (2005) Cell Metab "The prepared mind of the worm."

Antebi A

[Cell Metab, 2005]

In C. elegans, dauer pheromone is an indicator of population density and influences pathways that regulate metabolism, development, and aging. In a recent publication in Nature, Paik and coworkers (Jeong et al., 2005) show the purified substance to be a pyran ring conjugated to heptanoic acid, setting the stage for dissecting downstream signaling pathways.

Antebi A (2019) Curr Biol "Developmental Timing: Honey, I Reprogrammed the Kids."

Antebi A

[Curr Biol, 2019]

A new study finds that signaling pathways promoting developmental quiescence can reprogram developmental time.

Antebi A (2004) Neuron "Long life: a matter of taste (and smell)."

Antebi A

[Neuron, 2004]

Insulin/IGF signaling has emerged as a central regulator of metazoan aging. In C. elegans, insulin-like peptides are expressed predominately in neurons. Alcedo and Kenyon demonstrate that removal of specific gustatory and olfactory neurons result in longer life, suggesting that metazoan longevity is influenced by sensory perception.

Tuck S (2011) Curr Biol "Extracellular vesicles: budding regulated by a phosphatidylethanolamine translocase."

Tuck S

[Curr Biol, 2011]

Recent work on a Caenorhabditis elegans transmembrane ATPase reveals a central role for the aminophospholipid phosphatidylethanolamine in the production of a class of extracellular vesicles.

Kress E et al. (2011) Nat Cell Biol "Aurora A in cell division: kinase activity not required."

Kress E, Gotta M

[Nat Cell Biol, 2011]

Aurora A kinase is a key regulator of cell division, whose functions were attributed to its ability to phosphorylate diverse substrates. Aurora A is now shown to have a kinase-independent role in the regulation of chromatin-mediated microtubule assembly.

Musacchio A (2015) Elife "Closing the Mad2 cycle."

Musacchio A

[Elife, 2015]

Chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion.

Prosser SL et al. (2015) Curr Biol "Centrosome biology: the ins and outs of centrosome assembly."

Pelletier L, Prosser SL

[Curr Biol, 2015]

As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.

Louis T et al. (2014) Cell "Neurons and behavior: ex uno, plures."

Louis T, Tomchik SM

[Cell, 2014]

Li et al. demonstrate that a single interneuron can regulate analog- and digital-like behaviors guided by two different postsynaptic neurons. Releasing a single neurotransmitter onto downstream neurons that express receptors with distinct biophysical properties enables a small set of neurons to direct a range of functional responses.