Antebi A (2004) Neuron "Long life: a matter of taste (and smell)."

Antebi A

[Neuron, 2004]

Insulin/IGF signaling has emerged as a central regulator of metazoan aging. In C. elegans, insulin-like peptides are expressed predominately in neurons. Alcedo and Kenyon demonstrate that removal of specific gustatory and olfactory neurons result in longer life, suggesting that metazoan longevity is influenced by sensory perception.

Ambros V (2001) Science "Development. Dicing up RNAs."

Ambros V

[Science, 2001]

RNA molecules are a constant source of joy to molecular biologists: They come in all shapes and sizes, and perform diverse informational, structural, and catalytic tricks in living cells. Perhaps less appreciated is their facility for regulating gene expression. Small regulatory RNAs figure prominently in two fascinating phenomena: gene inactivation by RNA interference (RNAi), and the control of gene expression during development.