"At day 3, the higher sod-3::GFP levels after AZD2281 or NR treatment were not due to increased daf-16 gene expression, a key transcriptional regulator of antioxidant defense (Figure 4D)."
"At day 3, the higher sod-3::GFP levels after AZD2281 or NR treatment were not due to increased daf-16 gene expression, a key transcriptional regulator of antioxidant defense (Figure 4D)."
"Indeed, ubl-5 RNAi abrogated the lifespan extension conferred by both AZD2281 and NR treatment (Figures 3G and 3H). This coincided with the attenuation of UPRmt activation in ubl-5 RNAi worms (Figure 3I)."
"Indeed, ubl-5 RNAi abrogated the lifespan extension conferred by both AZD2281 and NR treatment (Figures 3G and 3H). This coincided with the attenuation of UPRmt activation in ubl-5 RNAi worms (Figure 3I)."