car-1 : cey-2

"CAR-1 associates with the Y-box containing protein CEY-2."

hsp-60 : nduf-7

"We therefore hypothesized that the et19 mutant may also be resistant to statins because of an activated mitochondrial stress response. Consistent with this hypothesis, et19 mutant worms constitutively express high levels of hsp-60::GFP, a known marker of UPRmt (Figure 2D) (Yoneda et al. 2004; Rauthan et al. 2013)."

hsp-4 : olaparib

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

hsp-6 : olaparib

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

N-ribosylnicotinamide : hsp-6

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

N-ribosylnicotinamide : hsp-4

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

N-ribosylnicotinamide : sod-3

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

olaparib : sod-3

"Both AZD2281 and NR induced a strong superoxide burst at day 1 of adulthood, although at this stage no protective activation of sod-3 expression was observed (Figure 3C). When we measured at the same age UPRmt activation using hsp-6::GFP reporter worms (Yoneda et al., 2004), both compounds robustly induced UPRmt (Figure 3D), without activating the ER-specific unfolded protein response (hsp-4::GFP; Figure 3E)."

egl-5 : vab-3

In contrast to wild-type, vab-3::gfp expression does not initiate in the tail of egl-5(n486) mutants, and is absent from the B and Y cell lineages.

cgh-1 : gld-2

In a strong gld-2 loss-of-function allele(q497) CGH-1 was appropriately upregulated at meiosis entr y and appeared to be localized normally through the pachytene stage, but expression of both CGH-1 and PGL-1 was lost more proximally, in the abnormal gametes that are produced.