"Elevated ROS levels appear essential for both the UPRmt activation and lifespan elongation in the nduf-7(et19) mutant because these phenotypes are abrogated by NAC, a hydrophilic antioxidant against all types of ROS (Aruoma et al. 1989; Benrahmoune et al. 2000; Yang and Hekimi 2010a) (Figure 6C, Figure 7)."
"Elevated ROS levels appear essential for both the UPRmt activation and lifespan elongation in the nduf-7(et19) mutant because these phenotypes are abrogated by NAC, a hydrophilic antioxidant against all types of ROS (Aruoma et al. 1989; Benrahmoune et al. 2000; Yang and Hekimi 2010a) (Figure 6C, Figure 7)."
100% of embryos lack endoderm in double mutants at 15 deg C and 25 deg C, whereas lit-1 mutants only exhibit this phenotype at 25 deg C and mom-2 mutants exhibit this phenotype only partially at 22 deg C.
"In wild-type embryos, CeGrip-1 colocalizes with c-tubulin at centrosomes during interphase (unpublished data) and mitosis (Fig. 4 C, left). In gip-1(RNAi) embryos, c-tubulin fails to target to centrosomes (n = 10 embryos; Fig. 4 C, right)"