3 Interactions found (0.057 seconds)

The RBG-1/SV co-localization is lost and mCherry::RBG-1 fluorescence becomes diffuse in snt-1 animals.

Authors observed that synaptic vesicle (SV) soma accumulations are further increased in the sam-4 unc- 104(js901) double mutant relative to either single mutant. Additionally, we found that sam-4 unc-104(js901) double mutants exhibit very severe locomotion defects relative to either single mutant, exhibiting defects comparable to severe unc-104 mutants. These results suggest that SAM-4 functions in concert with the UNC-104 protein to regulate the SV trafficking.

rab-3 : snt-1

In snt-1(md290) animals, which lack snt-1 function, the GFP::RAB-3 puncta disappeared and the GFP signal was diffusely distributed throughout the neuronal processes... In wild type, RAB-3 is highly enriched in membrane fractions, which is consistent with the SV localization of GTP-RAB-3. In contrast, the RAB-3 protein distribution is shifted to the soluble fraction when sent-1 is removed, suggesting a cytosolic localization of RAB-1 in snt-1 mutants.