crh-1 : jnk-1 : long-term memory training

"we used reporter transgenic worms in which GFP expression is controlled by the CRE reporter (pCRE::GFP) (Kimura et al., 2002). In untrained worms, CREB activity is barely detectible (Figure 4A). After spaced butanone/food long-term memory training, we observed fluorescence in two sets of neurons (Figures 4A and 4B)... pCRE::GFP expression in the SIA, where CREB is activated upon extended starvation (Suo et al., 2006) (Figure 4A), was expected, since our training paradigm involves cycling between starvation and food paired with butanone. Fluorescence in the SIA neurons was also observed upon mock training in the absence of butanone (Figure 4B). However, CREB rescue in the SIA neurons does not rescue LTAM (Figure 4E), suggesting that CREB activation in the SIA is not specific to or required for long-term memory."