aip-1 : succinylacetone

The treatment of worms with 0.5 mg/mL or 1.0 mg/mL succinylacetone,tyrosine degradation products, induced the expression of aip-1.

Treatment with BIBX1382. : hsp-16.1 : hsp-16.2 : hsp-16.41 : hsp-16.48

Exposure to the low concentration BIBX1382 0.1 mg/ml hardly induced beta-Galactosidase expression. At higher concentrations (e.g., 0.4 mg/ml), BIBX1382 showed lower levels of stress responses.

daf-16 : graphene oxide

DAF-16:GFP expression in the nuclei of GO exposed (100 mg/L) nematodes increased compared with control.

Chlorpyrifos : ced-3

The expression levels of ced-3 gene in MD701 nematodes exposed to 0.03-3.0 mg/l CPF was significantly increased.

Chlorpyrifos : glp-1

After exposure to CPF, the expression level of glp-1 gene was significantly increased in the 3.0 mg /1 CPF- exposed.

gpdh-1 : kasugamycin

"Worms were treated for 6 h on 51 mMNaCl agar plates containing either 1 mg/ml kasugamycin or 1 mg/ml cycloheximide. Kasugamycin inhibits translation initiation while cycloheximide blocks the elongation step of protein synthesis. As shown in Fig. 1E, both compounds elevated gpdh-1 mRNA levels 3-16 fold (P < 0.005)."

Cycloheximide : gpdh-1

"Worms were treated for 6 h on 51 mMNaCl agar plates containing either 1 mg/ml kasugamycin or 1 mg/ml cycloheximide. Kasugamycin inhibits translation initiation while cycloheximide blocks the elongation step of protein synthesis. As shown in Fig. 1E, both compounds elevated gpdh-1 mRNA levels 3-16 fold (P < 0.005)."

Treatment with BIBU1476. : hsp-16.1 : hsp-16.2 : hsp-16.41 : hsp-16.48

Transgenic PC72 nematodes exposed to the chemical analogue BIBU1476 displayed a weak beta-Galactosidase expression at the concentration 0.1 mg/ml. At the higher concentrations (e.g., 0.4 mg/ml BIBU1476), the animals showed minor levels of stress responses, and in comparison to BIBU1361 and BIBX1382, the expression of beta-Galactosidase was generally very low.

Cisplatin : asna-1

In C. elegans, we observed an increase in ASNA-1 protein levels after 48-hour exposure to 100 or 200 mg/mL cisplatin in agar plates (Fig. 1F). A 2.8 +/- 0.35-fold increase in the steady state levels of ASNA-1 protein was detected in worms exposed to 200 mg/mL cisplatin (P < 0.05).

Chlorpyrifos : spe-15

The expression levels of spe-15 gene in 0.3 and 3.0 mg/l CPF-exposed him-5 mutants was also significantly reduced.