hif-1(RNAi) suppresses the reduced response of pmk-1(km25) mutants to silver nanoparticles (AgNPs), both in terms of increased reproductive capacity (brood size) and reduced glutathione-S-transferase (GST) activity.
hif-1(RNAi); pmk-1(km25) double mutants exhibited a reactive oxygen species profile in response to silver nanoparticles (AgNPs) that was similar to hif-1(RNAi) suggesting that hif-1(RNAi) is epistatic to pmk-1(km25)